厚朴对胃肠动力障碍作用的研究

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Abstract Objective To investigate the mechanism of Magnoliae Officinalis Cortex on promoting gastrointestinal motility of mice. Methods Three hundred and four male ICR mice were randomly divided into low, medium, high dose of Magnoliae Officinalis Cortex extract groups (1, 2, 4 g/kg), low, medium, high dose of magnolol groups (40, 80, 160 mg/kg), positive control group (Etobil Hydrochloride, 50 mg/kg) and blank control group according to the body weight, with 8 mice in each group. The intestinal propulsive rate of normal mice, and the gastric empty and intestinal propulsive rate of Atropine (1 mg/kg) and Ondansetron (1.6 mg/kg) induced mice were measured respectively. The multi-channel physiological instrument was used to detect the muscle electrophysiological waveform. Results Compared with blank control group, the intestinal propulsive rates of normal mice in medium, high dose of Magnoliae Officinalis Cortex extract groups and medium, high dose of magnolol groups were significantly improved (P ＜ 0.05). Compared with Atropine model group, the gastric emptying rates in medium, high dose of Magnoliae Officinalis Cortex extract groups and low, medium, high dose of magnolol groups were significantly improved (P ＜ 0.05 or P ＜ 0.01). Compared with Atropine model group, the intestinal propulsive rates in high dose of Magnoliae Officinalis Cortex extract group and high dose of magnolol group were improved, the differences were statistically significant (P ＜ 0.05). Compared with Ondansetron model group, the gastric emptying rate and intestinal propulsive rate in high dose of magnolol group were improved, the differences were statistically significant (P ＜ 0.05). Conclusion Magnoliae Officinalis Cortex extract and magnolol can improve the gastric emptying rate and intestinal propulsive rate of mice, the positive effect for gastrointestinal motility may be connected with 5-HT3 receptor and M acetylcholine receptor.

Key words： Magnoliae Officinalis Cortex Gastric motility Small intestinal propulsion Magnolol

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	CHAO Lei1 CAO Yudan2 CHEN Peidong2 ZHANG Li2

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CHAO Lei1 CAO Yudan2 CHEN Peidong2 ZHANG Li2. Study on the effect of Magnoliae Officinalis Cortex on gastrointestinal motility disorders[J]. 中国医药导报, 2018, 15(13): 31-34.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2018/V15/I13/31

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