胶质母细胞瘤中IMP3、CD164的表达及临床意义

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Abstract Objective To investigate the expression and clinical significance of the oncogene IMP3 and sialomucin CD164 in glioblastoma (GBM) tissues. Methods One hundred and nineteen GBM paraffin-embedded samples from January 2011 to July 2015 in Anhui Provincial Hospital were collected. The expression of IMP3 and CD164 was detected by automated immunohistochemistry. The results were analyzed with clinical and pathological factors and the survival of patients. Results The high expression rates of IMP3 and CD164 were 69.7% (83/119) and 81.5% (97/119) respectively. There was a positive correlation between the two expression levels (r = 0.252, P = 0.006). In the connected analysis with clinical data, the expression of IMP3 was positively correlated with EGFR state (r = 0.242, P = 0.008), and was not significantly related to the gender, age, tumor size, tumor location and Ki67 proliferation index (P ＞ 0.05). CD164 expression was positively correlated with age (r = 0.285，P = 0.002) and EGFR (r = 0.249，P = 0.006), not other factors (P ＞ 0.05). The overall survival (OS) of patients with CD164 high expression were significantly shorter than those with low expression (P = 0.004). There was no significant correlation between IMP3 and OS alone (P = 0.056). Age and CD164 were independent prognostic factors of GBM (P = 0.036, 0.005). Conclusion The expression of CD164 in GBM is closely related to IMP3, and CD164 can be used as an independent predictor of poor prognosis of GBM.

Key words： Glioblastoma IMP3 CD164 Overall survival

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	WU Jing1
	2 WANG Jingjing2 LI Xiaojie2 HE Jie2
	3

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WU Jing1,2 WANG Jingjing2 LI Xiaojie2 HE Jie2,3. Expression and clinical significance of IMP3 and CD164 in glioblastomas[J]. 中国医药导报, 2018, 15(13): 4-8.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I13/4

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