颅脑外伤术后血清S100β及脑脊液P38蛋白与认知功能的关系

doi:10.20047/j.issn1673-7210.2023.07.21

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Abstract Objective To investigate the relationship between serum soluble protein-100β (S100β) and cerebrospinal fluid P38 mitogen-activated protein kinase (P38) protein and cognitive function after craniocerebral trauma. Methods Seventy-five cases with craniocerebral trauma from February 2016 to February 2021 in the 904th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army were selected, who were treated surgically, and serum S100β and cerebrospinal fluid P38 protein levels were measured and divided into postoperative cognitive dysfunction (POCD) group (≤26 points) and non-POCD group (＞26 points) according to the 15 d postoperative simple intelligence mini-mental state examination (MMSE) score. The general data and S100β and P38 protein levels of the two groups were compared, and logistic regression was used to analyze the influencing factors of POCD, while ROC was used to assess the predictive value of S100β and P38 protein in POCD. Results There were 21 patients with POCD and 54 patients without POCD in 75 cases 15 d after craniocerebral trauma, and the incidence of POCD was 28.00%. The GCS score of the POCD group was lower than that of the non-POCD group, while the percentage of temporal lobe injury and combined hypertension were higher than those of the non-POCD group, with statistically significant differences (P＜0.05). The S100β level in the POCD group was higher than that in the non-POCD group, while the P38 protein level was lower than that in the non-POCD group, with statistically significant differences (P＜0.05). Logistic regression analysis showed that GCS score, injury site, combined hypertension, S100β, and P38 protein were all risk factors for POCD (OR＞1, P＜0.05). ROC analysis showed that S100β and P38 proteins predicted POCD with cut-off values of 1.094 μg/L and 0.323, AUC values of 0.852 and 0.839, and AUC values of 0.942 for the combined assay. Conclusion After craniocerebral trauma the changes of S100 β and p38 protein in cerebrospinal fluid are closely related to cognitive function. It is not only the influencing factor of POCD, but also the reference factor to predict its occurrence.

Key words： Craniocerebral trauma Serum soluble protein-100β Cerebrospinal fluid p38 mitogen activated protein kinase Cognitive function

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	WANG Xiao MENG Lingwen▲

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WANG Xiao MENG Lingwen▲. Relationship between serum S100β and cerebrospinal fluid P38 protein and cognitive function after craniocerebral trauma[J]. 中国医药导报, 2023, 20(7): 97-100,109.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.07.21 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I7/97

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