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| Clinical effect of Tongxie Decoction on ulcerative colitis of damp-heat type of spleen and stomach |
| YE Jia1 ZHU Meiping1 SUN Mingyu2 LIU Chang1 |
1.Department of Gastroenterology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; 2.Hepatology Research Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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Abstract Objective To explore the clinical effect of Tongxie Decoction on the treatment of ulcerative colitis of damp-heat type of spleen and stomach. Methods A total of 88 patients with ulcerative colitis of damp-heat type of spleen and stomach admitted to Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from June 2021 to August 2022 were selected and they were divided into observation group and control group by random number table method, with 44 cases in each group. The control group was treated with Enteric Coated Sulfamethoxazole Tablets, while the observation group was treated with Tongxie Decoction on the basic of control group. A total of 15 days as a course of treatment, after three courses of treatment, clinical efficacy, the traditional Chinese medicine syndrome scores, intestinal mucosal barrier function, and treatment safety of the two groups were compared. Results The clinical effect of observation group was better than control group, the difference was statistically significant (P＜0.05). After treatment, the scores of diarrhea and blood stool, posterior gravity, anal burning, and tongue red and moss yellow in two groups were lower than those before treatment, and the observation group were lower than those in control group, the differences were statistically significant (P＜0.05). After treatment, the levels of diamine oxidase, endotoxin, and D-lactic acid in two groups were lower than before treatment, and the observation group were lower than those in control group, the differences were statistically significant (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion Tongxie Decoction has a significant therapeutic effect on ulcerative colitis of deep-heat type of spleen and stomach, which can improve traditional Chinese medicine syndrome and enhance intestinal mucosal barrier function.
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[1] 吴航，陈莉娟，杨维建，等.中医药治疗溃疡性结肠炎及其肺损伤的机制研究[J].中国中医基础医学杂志，2023， 29（2）：339-344.
[2] Danese S，Levesque BG，Feagan BG，et al. Randomised clinical trial： a phase 1b study of GB004，an oral HIF-1α stabiliser，for treatment of ulcerative colitis [J]. Aliment Pharmacol Ther，2022，55（4）：401-411.
[3] 刘峰，刘林，王垂杰.溃疡性结肠炎病因病机及治疗进展[J].山东中医药大学学报，2021，45（1）：143-147.
[4] 张涛，苏晓兰，毛心勇，等.溃疡性结肠炎中西医多维度诊疗策略[J].世界中西医结合杂志，2021，16（5）：972-976.
[5] 唐瑞，徐苏颖，杨男，等.中药组方联合美沙拉嗪/柳氮磺吡啶治疗溃疡性结肠炎有效性及安全性的系统评价[J].中国医院药学杂志，2021，41（20）：2113-2120.
[6] 李玉，赵琳，李上达，等.翁榆合剂联合中医特色护理对慢性非特异性溃疡性结肠炎（湿热内蕴证）的临床疗效观察[J].四川中医，2020，38（5）：211-213.
[7] 中华医学会消化病学分会炎症性肠病学组.炎症性肠病诊断与治疗的共识意见（2018 年，北京）[J].中华消化杂志，2018，38（5）：292-311.
[8] 中华中医药学会脾胃病分会，沈洪，唐志鹏，等.消化系统常见病溃疡性结肠炎中医诊疗指南（基层医生版）[J].中华中医药杂志，2019，34（9）：4155-4160.
[9] 马国平，王博，李红方，等.西医诊断技术在现行中医病证诊断及疗效标准中的应用研究[J].中国全科医学，2012，15（28）：3310-3312.
[10] 中国中西医结合学会消化系统疾病专业委员会.溃疡性结肠炎中西医结合诊疗共识意见（2017年）[J].中国中西医结合消化杂志，2018，26（2）：105-111，120.
[11] 罗瑞娟，柳越冬，陶弘武，等.基于“肺-肠轴”理论探讨溃疡性结肠炎的发病机制[J].辽宁中医药大学学报，2022，24（8）：32-36.
[12] 孙莉莉，薛青.粪微生态移植联合柳氮磺吡啶对溃疡性结肠炎患者血清炎症因子及T细胞亚群的影响[J].临床输血与检验，2021，23（4）：497-501.
[13] 刘亚军，沈洪.沈洪中西医结合治疗溃疡性结肠炎的经验[J].中医药导报，2021，27（10）：177-180.
[14] 张娇娇，张帆，余星星，等.溃疡性结肠炎发病机制及中西医治疗研究进展[J].辽宁中医药大学学报，2021，23（1）：70-74.
[15] 罗瑞娟，柳越冬，潘海鸥，等.基于“肺与大肠相表里”理论的溃疡性结肠炎中医药治疗研究进展[J].中华中医药学刊，2022，40（5）：58-61.
[16] 孟梦，周强，朱春洋，等.张声生教授辨治溃疡性结肠炎中医临证经验[J].世界中医药，2022，17（6）：838-842.
[17] 郝民琦，王佳慧，李晓玲，等.基于网络药理学与分子对接探讨黄芪治疗溃疡性结肠炎的作用机制[J].中国药房，2021，32（10）：1215-1223.
[18] 焦瑶，袁亚利，王乾皓，等.基于网络药理学的黄芩-黄连治疗溃疡性结肠炎作用机制探讨[J].临床药物治疗杂志，2021，19（7）：48-54.
[19] 许琳，王凤云，李娟娟，等.基于数据挖掘的国医大师治疗溃疡性结肠炎用药规律研究[J].中国中医药信息杂志，2021，28（5）：14-19.
[20] 蔡兴炎，李枝锦，林力森，等.愈肠止痢方对活动期溃疡性结肠炎患者疾病活动度及肠黏膜屏障功能的影响[J].现代中西医结合杂志，2021，30（25）：2816-2819.
[21] 朱东东，孙孟甜.肠道菌群与溃疡性结肠炎患者血清ET、SOCS-3、TLRs水平的相关性[J].中国微生态学杂志，2021， 33（4）：436-440.
[22] 冯欣伟，沈卫萍，王艳，等.清肠愈疡汤治疗溃疡性结肠炎对血清I-FABP、sRAGE和D-LAC水平的影响[J].检验医学与临床，2021，18（11）：1574-1578.
[23] 王玥，郭龙龙，李欢，等.健脾活血解毒汤联合美沙拉嗪治疗轻中度溃疡性结肠炎的疗效及其对MMP-9与ANCA的影响[J].临床和实验医学杂志，2022，21（22）：2403-2406.
[24] 付荣华，郑勇，郑春菊.怡情止泻汤联合美沙拉嗪治疗溃疡性结肠炎临床效果观察[J].中华中医药学刊，2022， 40（12）：244-247.
[25] 邹林焘，邹正华，杜学芳.清肠解毒汤治疗溃疡性结肠炎湿热内蕴证临床研究[J].陕西中医，2021，42（5）：597- 600.
[26] 王晓瑜，缪志伟，张耀辉，等.清肠汤联合美沙拉嗪治疗热盛血瘀型活动期溃疡性结肠炎患者的临床效果及其作用机制[J].中国医药导报，2022，19（19）：115-119.
[27] 亢秀红，张立宏，王颖超，等.从健脾清化祛瘀论治溃疡性结肠炎[J].中国医药科学，2021，11（21）：100-103，107.
[28] 赵颖，张小琴.中医药修复肠黏膜屏障治疗溃疡性结肠炎的研究进展[J].中国中医急症，2021，30（5）：936-940. |
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