Efficacy of lymphocyte count, interleukin-6, and interleukin-10 combined detection in sepsis early screening
FU Xiaoying1 LIU Bin2 LIU Xiao1 DU Huimin3 HE Faming1 NIU Bailin1
1.Department of Emergency and Critical Care Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China;
2.Department of Critical Care Medicine, Chongqing University Central Hospital Chongqing Emergency Medical Center, Chongqing 400010, China; 3.Department of Oncology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Abstract Objective To evaluate the efficacy of lymphocyte count (Lym), interleukin-6 (IL-6), and interleukin-10 (IL-10) combined detection in sepsis early screening. Methods A total of 153 infected patients admitted to the First Affiliated Hospital of Chongqing Medical University from January 2021 to March 2022 were selected. Patients with Sepsis-3 were classified into sepsis group (81 cases) and non-sepsis group (72 cases). Serum Lym, IL-6, and IL-10 and other indicators were collected within 2 h after the onset of sepsis, the influencing factors of the occurrence of sepsis were analyzed, the diagnostic efficacy of Lym, IL-6, and IL-10 on sepsis was analyzed by receiver operating characteristic curve. Results Lym and lymphocyte percentage (L%) in sepsis group were lower than those in non-sepsis group, and age, IL-6, IL-10, and neutrophil count/lymphocyte count ratio were higher than those in non-sepsis group, with statistical significance (P＜0.05). Lym and L% were protective factors for sepsis (OR=0.141, 0.798, P＜0.05), IL-6 and IL-10 were risk factors for sepsis (OR=1.007, 1.080, P＜0.05). The area under the curve of Lym, IL-6, and IL-10 combined detection was higher than that of each single detection, with statistical significance (P＜0.05). Conclusion Lym, IL-6, and IL-10 are closely related to sepsis, and the combined detection of sepsis is better than that of detection alone.
FU Xiaoying1 LIU Bin2 LIU Xiao1 DU Huimin3 HE Faming1 NIU Bailin1. Efficacy of lymphocyte count, interleukin-6, and interleukin-10 combined detection in sepsis early screening[J]. 中国医药导报, 2023, 20(14): 123-127.
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