Clinical observation of modified Danggui Sini Decoction in the treatment of primary dysmenorrhea with syndrome of coagulation cold due to blood deficiency#br#
HU Xinxin SUN Yun MA Dazheng GAO Chuchu
Department of Gynecology, Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Zhejiang Province, Wenzhou 325000, China
Abstract Objective To investigate clinical effect of modified Danggui Sini Decoction in the treatment of primary dysmenorrhea with syndrome of coagulation cold due to blood deficiency. Methods One hundred and twenty patients with primary dysmenorrhea treated in Department of Gynecology of Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University from January 2018 to June 2020 were selected and divided into control group and treatment group according to random number table method, with 60 cases in each group. Control group began to take Ibuprofen Sustained Release Capsules orally at the onset of menstruation for three days. Treatment group began to take Danggui Sini Decoction seven days before menstruation, it lasted until menstruation for three days, two groups were given continuous treatment of three menstrual cycl. Clinical efficacy, dysmenorrhea symptom score, visual analogue scale (VAS), the MOS item short from health survey (SF-36) score and traditional Chinese medical syndrome score were compared between two groups. Results Clinical effect of treatment group was better than that of control group, the difference was statistically significant (P < 0.05). The overall analysis showed that there were significant differences in dysmenorrhea symptom score, VAS score and SF-36 score between groups, time points and interaction (P < 0.05). Intra group comparison: dysmenorrhea symptom score and VAS score of two groups after treatment and three months after drug withdrawal were lower than those before treatment, and SF-36 score of two groups after treatment and three months after drug withdrawal was higher than that before treatment, the differences were statistically significant (P < 0.05); dysmenorrhea symptom score and VAS score of control group three months after drug withdrawal were higher than those after treatment, and SF-36 score of control group three months after drug withdrawal was lower than that after treatment, the differences were statistically significant (P < 0.05); VAS score of treatment group three months after drug withdrawal was higher than that after treatment, and SF-36 score of treatment group three months after drug withdrawal was lower than that after treatment, the differences were statistically significant (P < 0.05). Comparison between groups: dysmenorrhea symptom score and VAS score of treatment group were lower than those of control group, and SF-36 score of treatment group was higher than that of control group, the differences were statistically significant (P < 0.05). The scores of irritability, cold sweat, nausea and vomiting, anal distension in two groups after treatment were lower than those before treatment, the differences were statistically significant (P < 0.05). The scores of breast pain and limb chills in treatment group after treatment were lower than those before treatment, the differences were statistically significant (P < 0.05). The scores of irritability and limb chills in treatment group were lower than those in control group, the differences were statistically significant (P < 0.05). Conclusion Modified Danggui Sini Decoction can improve clinical effect of patients with primary dysmenorrhea of syndrome of coagulation cold due to blood deficiency, reduce dysmenorrhea symptom score and VAS score, increase SF-36 score, and improve menstrual irritability, cold sweat, nausea and vomiting, anal distension, breast pain and limb chills.
HU Xinxin SUN Yun MA Dazheng GAO Chuchu. Clinical observation of modified Danggui Sini Decoction in the treatment of primary dysmenorrhea with syndrome of coagulation cold due to blood deficiency#br#[J]. 中国医药导报, 2022, 19(7): 132-136.
