Abstract Objective To analyze the influencing factors of perimenopausal symptoms after laparoscopic hysterectomy for benign uterine lesions. Methods A retrospective analysis was performed on the clinical data of 79 benign uterine lesions patients who underwent laparoscopic total hysterectomy in Changzhou Second People’s Hospital Affiliated to Nanjing Medical University from March 2018 to March 2020. The levels of sex hormones were measured before operation, one month after operation, and one year after operation, the modified Kupperman score scale was used to assess perimenopausal symptoms, the incidence of perimenopausal symptoms in patients with benign lesions undergoing laparoscopic total hysterectomy for one year after operation was counted, the influencing factors of perimenopausal symptoms in patients with benign lesions undergoing laparoscopic total hysterectomy were analyzed. Results A total of 79 patients were followed up for one year, and one patient was lost, which was not included in the statistics. One year after operation, the levels of estradiol, progesterone, and testosterone in patients with benign lesions undergoing laparoscopic total hysterectomy were lower than those of one month after operation and before operation, the levels of follicle stimulating hormone and luteinizing hormone were higher than those of one month after operation and before operation, and the differences were statistically significant (P < 0.05); one month after operation, the levels of estradiol, progesterone, and testosterone in patients with benign lesions undergoing laparoscopic total hysterectomy were lower than those before operation, the levels of follicle stimulating hormone and luteinizing hormone were higher than those before operation, and the difference were statistically significant (P < 0.05). One year after operation, perimenopausal symptoms occurred in 31 patients, and the incidence rate was 39.74%. Menopause and the levels of estradiol, progesterone, follicle stimulating hormone, luteinizing hormone, and testosterone were significantly different in patients with and without perimenopausal symptoms of one month after operation (P < 0.05). Menopause and the levels of estradiol, progesterone, and testosterone were independent risk factors for perimenopausal symptoms patients with benign lesions undergoing laparoscopic total hysterectomy (OR > 1, P < 0.05). Conclusion The levels of serum estradiol, progesterone, and testosterone are abnormally decreased, and the levels of follicle stimulating hormone and luteinizing hormone are abnormally increased in patients with benign lesions undergoing laparoscopic total hysterectomy, moreover, such patients are prone to perimenopausal symptoms. serum estradiol, testosterone, and progesterone levels are independent risk factors for perimenopausal symptoms in patients with benign lesions undergoing laparoscopic total hysterectomy.
DOU Shulan DING Ling SHI Ruxia▲. Analysis of influencing factors of perimenopausal symptoms after laparoscopic total hysterectomy for benign uterine lesions#br#[J]. 中国医药导报, 2022, 19(6): 102-105,134.
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