雾化吸入硫酸镁联合沙丁胺醇治疗儿童哮喘有效性和安全性的meta分析

doi:10.20047/j.issn1673-7210.2022.35.18

Abstract
Figure/Table
References (26)
Related Citation (15)

Download: PDF (2449 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To provide evidence-based medical evidence for the clinical treatment of children with this disease through a meta-analysis of the efficacy and safety of nebulized inhaled magnesium sulfate in combination with salbutamol in the treatment of childhood asthma. Methods The randomized controlled trials (RCTs) of nebulized magnesium sulfate combined with salbutamol (trial group) and nebulized salbutamol (control group) for the treatment of asthma in children were collected by searching PubMed, Cochrane Library, Embase, China Knowledge Network, Wanfang database, VIP Chinese journal database, and Chinese biomedical literature database from the establishment of the database to July 2021. The RCTs were screened according to the established inclusion and exclusion criteria, data were extracted and the quality of included studies was evaluated according to the Cochrane risk of bias assessment scale, and meta-analysis was performed using RevMan 5.3 software. Results A total of 14 RCTs with a total of 1 198 patients were included in this study. The results of meta-analysis showed that the total clinical efficiency (RR = 1.15, 95%CI: [1.09, 1.20], P ＜ 0.000 01), forced expiratory volume in first second (MD = 0.10, 95%CI: [-0.02, 0.18], P = 0.02), and peak expiratory flow (MD = 0.38, 95%CI: [0.26, 0.49], P ＜ 0.000 01) in the trial group were higher than those in the control group, and the differences were statistically significant. There was no significant difference in the incidence of adverse reactions between the two groups(P ＞ 0.05). Conclusion Nebulized inhalation of magnesium sulfate combined with salbutamol can effectively improve the clinical efficacy and lung function indexes of children with asthma, and its safety is comparable to that of salbutamol alone.

Key words： Magnesium sulfate Salbutamol Nebulized Asthma Children Meta-analysis Efficacy Safety

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Xinyue LI Jiangya LIN Haochang ZHANG Qian LIANG Liju WENG Zhiying

Cite this article:

ZHANG Xinyue LI Jiangya LIN Haochang ZHANG Qian LIANG Liju WENG Zhiying. Meta-analysis of the effectiveness and safety of nebulized inhaled magnesium sulfate combined with salbutamol in the treatment of asthma in children[J]. 中国医药导报, 2022, 19(35): 78-83.

URL:

https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2022.35.18 OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I35/78

[1] 支气管哮喘防治指南（2020年版）[J].中华结核和呼吸杂志，2020，43（12）：1023-1048.
[2] 中华医学会儿科学分会呼吸学组，《中华儿科杂志》编辑委员会. 儿童支气管哮喘诊断与防治指南（2016年版）[J].中华儿科杂志，2016（3）：167-181.
[3] Davalos Bichara M，Goldman RD. Magnesium for treatment of asthma in children [J]. Can Fam Physician，2009，55（9）：887-889.
[4] Mahajan P，Haritos D，Rosenberg N，et al. Comparison of nebulized magnesium sulfate plus albuterol to nebulized albuterol plus saline in children with acute exacerbations of mild to moderate asthma [J]. Journal of Emergency Medicine，2004，27（1）：21-25.
[5] Sarhan HA,El-Garhy OH,Ali MA et al. The efficacy of nebulized magnesium sulfate alone and in combination ith salbutamol in acute asthma [J]. Drug Des Devel Ther，2016，10: 1927-1933.
[6] Guerrera MP，Volpe SL，Mao JJ. Therapeutic uses of magnesium[J]. Am Fam Physician，2009，80（2）：157-162.
[7] Bateman ED，Hurd SS，Barnes PJ，et al. Global strategy for asthma management and prevention：GINA executive summary [J]. Eur Respir J，2008，31（1）：143- 178.
[8] Global Initiative for Asthma Management and Prevention，2020.Available from[R/OL].https//ginasthma.org/：www.ginasthma.org.
[9] Blitz M，Blitz S，Beasely R，et al. Inhaled magnesium sulfate in the treatment of acute asthma [J]. Cochrane Database Syst Rev，2005（3）：Cd003898.
[10] Higgins JP，Altman DG，G?覬tzsche PC，et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials [J]. BMJ （Clinical research ed），2011，343（d5928.
[11] 谷鸿秋，王杨，李卫.Cochrane偏倚风险评估工具在随机对照研究Meta分析中的应用[J].中国循环杂志，2014， 29（2）：147-148.
[12] Haqq MA，Rahman MH，Mannan SKA. Efficacy of nebulized magnesium sulfate in the treatment of acute exacerbation of asthma in children [J]. Bangladesh Journal of Pharmacology，2006，1（2）：72-80.
[13] 陈俊锋，何志坚，吴冬红，等.硫酸镁联合沙丁胺醇雾化吸入治疗儿童哮喘急性发作的疗效评估[J].中国校医，2018，32（3）：213-214.
[14] 邓鲲，王红梅，肖红艳.沙丁胺醇联合硫酸镁治疗小儿哮喘的临床效果评价[J].母婴世界，2019（14）：110.
[15] 李晓辉.沙丁胺醇联合硫酸镁联合治疗小儿哮喘的临床效果分析[J].临床研究，2018，26（12）：74-75.
[16] 梁木华，林树林，谢丹.硫酸镁联合硫酸沙丁胺醇雾化治疗小儿支气管哮喘的应用价值[J].华夏医学，2020， 33（1）：112-115.
[17] 王慧，龚财惠，袁小平，等.硫酸镁雾化吸入对儿童肺功能影响研究[J].中国实用儿科杂志，2013，28（12）：913- 916.
[18] 王剑.沙丁胺醇联合硫酸镁治疗小儿哮喘的效果及对患儿T淋巴细胞亚群的影响[J].河南医学研究，2017， 26（11）：2053-2054.
[19] 王远照，王厚眷，朱建国，等.硫酸镁与喘乐宁联合吸入治疗小儿哮喘疗效观察[J].中国实用儿科杂志，2003， 18（2）：105-106.
[20] 项冕，陈文婷.硫酸镁联合硫酸沙丁胺醇雾化治疗小儿支气管哮喘对患儿肺功能的影响[J].现代医学与健康研究电子杂志，2020，4（20）：4-6.
[21] 熊锦清，柯桦，王春容.硫酸镁联合硫酸沙丁胺醇雾化吸入治疗儿童哮喘急性发作的临床观察[J].广东医学院学报，2015，33（4）：482-484.
[22] 张磊，汤昱.雾化吸入硫酸沙丁胺醇联合硫酸镁对哮喘急性发作患儿肺功能的影响[J].河南医学研究，2017， 26（18）：3325-3326.
[23] 周舒婷.雾化吸入硫酸镁对哮喘急性发作儿童肺功能的影响[D].重庆：重庆医科大学，2014.
[24] 朱惠娟，梅梅.硫酸镁与喘乐宁联合雾化吸入治疗小儿哮喘急性发作的观察与护理[J].护理实践与研究，2008， 5（24）：22-23.
[25] Papi A，Blasi F，Canonica GW，et al. Treatment strategies for asthma：reshaping the concept of asthma management [J]. Allergy Asthma Clin Immunol，2020，16：75.
[26] 杨磊.沙丁胺醇联合硫酸镁联合治疗小儿哮喘的临床效果评价[J].糖尿病天地，2019，16（5）：90.