Clinical effect of Qishen Granules in the treatment of type 2 diabetes mellitus patients with ophthalmoxerosis with deficiency of both qi and yin
JU Pin1 ZHAO Lei2 LI Yuexin1 ZUO Tao2
1.Graduate School, Liaoning University of Traditional Chinese Medicine, Liaoning Province, Shenyang 110032, China;
2.Department of Ophtalmology, the Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Liaoning Province, Shenyang 110034, China
Abstract Objective To observe the clinical effect of Qishen Granules in the treatment of type 2 diabetes mellitus patients with ophthalmoxerosis with deficiency of both qi and yin. Methods From December 2020 to May 2021, 74 type 2 diabetes mellitus patients with ophthalmoxerosis with deficiency of both qi and yin (148 eyes in total) admitted to the Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine were collected and divided into control group and treatment group according to the random number table method, with 37 cases in each group. The control group was given 0.3% Sodium Hyaluronate Eye Drops, and the treatment group was given Qishen Granules orally on this basis. The treatment course was 14 days in both groups. Keratograph 5M ocular surface analyzer was used to measure the relevant indicators before and after treatment, including the non-invasive first tear film break-up time (NIBUTf), non-invasive average tear film break-up time (NIBUTav), lacrimal river height (LTMH), meibomian gland loss score, and ocular surface disease index (OSDI). Results After treatment, the OSDI in the two groups were lower than those before treatment, and the treatment group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). After treatment, NIBUTf and LTMH in the two groups were higher than those before treatment, NIBUTav in the treatment group was higher than that before treatment, and NIBUTf, NIBUTav, and LTMH in the treatment group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). After treatment, the meibomian gland loss scores in the treatment group was lower than that before treatment and the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Qishen Granules can effectively improve the main symptoms of type 2 diabetes mellitus patients with ophthalmoxerosis with deficiency of both qi and yin, and the value of clinical promotion.
JU Pin1 ZHAO Lei2 LI Yuexin1 ZUO Tao2. Clinical effect of Qishen Granules in the treatment of type 2 diabetes mellitus patients with ophthalmoxerosis with deficiency of both qi and yin[J]. 中国医药导报, 2022, 19(33): 96-99.
