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Effect of self-made Huatan Huoxue Tongluo Decoction in the treatment of cerebral infarction with phlegm and blood stasis obstructing collateral syndrome during early recovery |
DENG Di XU Qiqi WANG Shaomin LI Zhen▲#br# |
Department of Emergency Internal Medicine, Bozhou Hospital of Traditional Chinese Medicine, Anhui Province, Bozhou 236800, China |
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Abstract Objective To explore the effect of self-made Huatan Huoxue Tongluo Decoction in the treatment of cerebral infarction with phlegm and blood stasis obstructing collateral syndrome during early recovery. Methods A total of 80 patients with cerebral infarction with phlegm and blood stasis obstructing collateral syndrome in the early recovery period treated in Bozhou Hospital of Traditional Chinese Medicine, Anhui Province from October 2018 to September 2021 were selected, and they were divided into control group and study group according to the random number table method, with 40 cases in each group. The control group was treated with routine treatment, and the study group was treated with self-made Huatan Huoxue Tongluo Decoction on the basis of the control group. After two months of treatment, the clinical efficacy, neurological impairment, degree of neurological dysfunction, ability of daily living activities and incidence of adverse reactions were compared between the two groups. Results The clinical efficacy of the study group was better than that of the control group, the difference was statistically significant (P < 0.05). After treatment, National Institutes of Health stroke scale (NIHSS) scores and modified Rankin scale (mRS) scores of the two groups were lower than those before treatment, the Barthel index (BI) scores of the two groups were higher than those before treatment, and the NIHSS scores and mRS scores of the study group were lower than those of the control group, and the BI scores of the study group were higher than those of the control group, the differences were statistically significant (P < 0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P > 0.05). Conclusion Self-made Huatan Huoxue Tongluo Decoction is effective in treating cerebral infarction patients with phlegm and blood stasis obstructing collateral syndrome during early recovery, which can significantly improve the patient’s nerve function and the ability of daily living activities.
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[1] Jiang Q,Xiao S,Shu L,et al. Pituitary apoplexy leading to cerebral infarction:a systematic review [J]. Eur Neurol,2020,83(2):121-130.
[2] Cannistraro RJ,Badi M,Eidelman BH,et al. CNS small vessel disease:a clinical review [J]. Neurology,2019,92(24):1146-1156.
[3] 陈擘璨.针对性护理对急性脑梗死患者神经功能及生活质量的影响[J].基因组学与应用生物学,2019,38(1):369-374.
[4] 邓瑜.脑梗死后失语应用丁苯肽注射液治疗的效果及患者语言功能改善情况分析[J].中国医药科学,2020,10(23):114-116.
[5] Fang H,Zhou H,Zhang J,et al. Effects of shuxuetong injection for cerebral infarction:a protocol for systematic review and meta-analysis [J]. Medicine(Baltimore),2020, 99(35):e21929.
[6] 王亚芳.阿司匹林联合长春西汀治疗脑梗死的效果研究[J].中国医药科学,2021,11(14):185-187.
[7] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246-257.
[8] 国家中医药管理局脑病急诊协作组.中风病诊断与疗效评定标准(试行)[J].北京中医药大学学报,1996,19(1):55-56.
[9] Kwah LK,Diong J. National Institutes of Health stroke scale(NIHSS) [J]. J Physiother,2014,60(1):61.
[10] Quinn TJ,Dawson J,Walters MR,et al. Reliability of the modified rankin scale:a systematic review [J]. Stroke,2009,40(10):3393-3395.
[11] Shah S,Vanclay F,Cooper B. Improving the sensitivity of the Barthel Index for stroke rehabilitation [J]. J Clin Epidemiol,1989,42(8):703-709.
[12] Wang Q,Yu H,Jiang C,et al. Cerebral infarction as initial presentation in stress cardiomyopathy:case report and literature review [J]. Medicine(Baltimore),2018,97(20):e10804.
[13] Takeda H,Yamaguchi T,Yano H,et al. Microglial metabolic disturbances and neuroinflammation in cerebral infarction [J]. J Pharmacol Sci,2021,145(1):130-139.
[14] 常永霞,李姣,侯文丽,等.涤痰汤合桃红四物汤加减对脑梗死恢复早期痰瘀阻络证脑神经的保护作用[J].中国实验方剂学杂志,2021,27(1):135-140.
[15] 张丹丹,富苏,马雪颜,等.真实世界中通络化痰胶囊治疗脑梗死恢复期痰瘀阻络证的疗效与安全性评价[J].中医杂志,2020,61(1):42-47.
[16] 金泽,陈静,侯鑫磊,等.天丹通络胶囊治疗脑梗死恢复期风痰瘀血痹阻脉络证临床疗效观察[J].中国实验方剂学杂志,2021,27(13):58-64.
[17] 王彤,王淼,胡楠.脑梗死康复期患者中医证型与自我管理能力的调查研究[J].辽宁中医杂志,2020,47(7):105-108.
[18] 杨明,程玉静,管士伟,等.中药治疗痰湿体质脑梗死恢复期患者的疗效研究[J].中国现代医学杂志,2018,28(2):69-72.
[19] 惠振,王敬卿.“滋肾养肝、化痰消瘀”法与脑梗死后血管新生理论探讨[J].辽宁中医杂志,2020,47(11):67-68.
[20] 张克飞,王兵.平肝涤痰通络汤联合常规治疗对脑梗死恢复期患者的临床疗效[J].中成药,2018,40(3):554-557.
[21] 张家明,余妮,任醒华,等.桂枝茯苓方在脑血管疾病中的应用及作用机制研究进展[J].中草药,2017,48(24):5276-5280.
[22] 曾德毅,黄楚栓,蔡彦.益气活血方联合针灸对脑梗死下肢偏瘫患者氧化应激指标和肢体功能的影响[J].中国中西医结合急救杂志,2019,26(6):669-673.
[23] 胡瑞学,于丹丹,李慧敏,等.基于2种复杂网络分析方法探索活血化瘀类中药注射液治疗急性脑梗死的疗效[J].中国中药杂志,2021,46(14):3722-3731.
[24] 刘克万,刘晓薇,缪靓靓,等.补阳还五汤联合高压氧治疗气虚血瘀型急性脑梗死的疗效观察[J].中华航海医学与高气压医学杂志,2020,27(6):691-695.
[25] 魏青.加味补阳还五汤联合西药对脑梗死患者临床疗效[J].世界中医药,2018,13(6):1397-1400.
[26] 路永坤,杨海燕,刘向哲,等.补阳还五汤佐治超早期脑梗死患者对静脉溶栓后出血性转化的影响[J].中国中药杂志,2019,44(8):1696-1703.
[27] 宋彬,洪春丽,郝欣,等.补阳还五汤联合针刺对急性脑梗死脑灌注、血同型半胱氨酸和内脏脂肪组织源性丝氨酸蛋白酶抑制剂水平的影响[J].中国医药科学,2021, 11(7):93-95,102. |
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