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| Discussion on the medication rules of urticaria in Song Dynasty based on data mining |
| ZHANG Xiaoyan1 CHENG Haoyang1 QU Jianhua2 |
1.College of Clinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;
2.Department of Dermatology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China |
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Abstract Objective To explore the medication rules of urticaria in Song Dynasty based on data mining, in order to provide reference for clinical treatment. Methods The literature on the treatment of urticaria in the Song Dynasty surgical classics of Chinese Medical Code was collected and sorted out, and the prescription and drug information was extracted. The prescription database was established by Microsoft Office Excel 2019, and the medication frequency, drug category, four nature of drugs and five flavors and channel tropism were counted. IBM SPSS Statistics 22.0 and IBM SPSS Modeler 14.1 software were used for association rule analysis and cluster analysis of high-frequency drugs (frequency > 10 ). Results A total of 97 prescriptions and 161 Chinese traditional medicines were included, among which the top three were Saposhnikoviae Radix, Glycyrrhizae Radix Et Rhizoma, Tribulus Terrestris. Superficies-relieving drugs and tonifying deficiency drugs were the most widely used. The drug properties were mainly warm, cold and flat drugs, drug tastes were mainly bitter, spicy and sweet tastes, which mainly belong to the liver, spleen and lung channels. Six core drug combinations were obtained by high frequency drug cluster analysis. Conclusion The treatment of urticaria in Song Dynasty mainly focuses on relieving the surface and dispelling cold, dispelling wind and clearing heat, tonifying qi and blood, emphasizing the combination of strengthening vital qi to eliminate pathogenic factor, qi and blood, and the harmony of mind and body, which can be used for clinical reference.
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[1] Zuberbier T，Aberer W，Asero R，et al. The EAACI/GA2 LEN/EDF/WAO guideline for the definition，classification，diagnosis and management of urticaria [J]. Allergy，2018，73（7）：1393-1414.
[2] Bernstein JA，Lang DM，Khan DA，et al. The diagnosis and management of acute and chronic urticaria：2014 update [J]. J Allergy Clin Immunol，2014，133（5）：1270-1277.
[3] Palgan K，Bartuzi Z. Platelet activating factor in allergies [J]. Int J Immunopathol Pharmacol，2015，28（4）：584-589.
[4] Wang D，Tang H，Shen Y，et al. Activation of the blood coagulation system in patients with chronic spontaneous urticaria [J]. Clin Lab，2015，61（9）：1283-1288.
[5] 中华医学会皮肤性病学分会荨麻疹研究中心.中国荨麻疹诊疗指南（2018版）[J].中华皮肤科杂志，2019，52（1）：1-5.
[6] Bishnoi A，Parsad D，Vinay K，et al. Phototherapy using narrow-band ultraviolet B and psoralen plus ultraviolet A is beneficial in steroid-dependent antihistamine-refractory chronic urticaria：a randomized，prospective observer-blinded comparative study [J]. Br J Dermatol，2017，176（1）：62-70.
[7] 赵作涛.2020年荨麻疹领域的重要进展[J].中华医学信息导报，2021，36（4）：19.
[8] 刘辉.两宋地方官药局研究[D].桂林：广西师范大学，2019.
[9] 孟永亮.北宋校正医书局研究[D].北京：北京中医药大学，2014.
[10] 舒畅，尹波，谢正强.中华医典[M].成都：四川大学，2021.
[11] 国家药典委员会.中华人民共和国药典[M].一部.北京：中国医药科技出版社，2020．
[12] 国家中医药管理局《中华本草》编委会.中华本草[M].上海：上海科学技术出版社，1999.
[13] 钟赣生.中药学[M].北京：中国中医药出版社，2016.
[14] 黄宽，顾炜.荨麻疹历史源流考究[J].福建中医药，2021， 52（6）：42-45.
[15] 张仲景.金匮要略[M].呼和浩特：内蒙古人民卫生出版社，2006：144.
[16] 赵炳南，张志礼.简明中医皮肤病学[M].北京：中国中医药出版社，2014：165-166.
[17] 王和平，赵雅宁，陈秋旸，等.中医药治疗荨麻疹的研究进展[J].中医药信息，2018，35（2）：123-127.
[18] 张苍，李伯华，王乐，等.论慢性荨麻疹的中医核心病机与辨治思路[J].北京中医药，2019，38（5）：403-406.
[19] 李时珍.本草纲目[M].北京：中国中医药出版社，1998：343.
[20] 张山雷.本草正义[M].福州：福建科学技术出版社，2006：82.
[21] 曹思思，史磊，孙佳琳，等.防风的化学成分及药理作用研究进展[J].现代中药研究与实践，2021，35（1）：95-102.
[22] 李祥生.防风对Ⅰ型变态反应治疗作用研究[D].保定：河北大学，2021.
[23] 李葆林，麻景梅，田宇柔，等.甘草中新发现化学成分和药理作用的研究进展[J].中草药，2021，52（8）：2438-2448.
[24] 王安铸，马晓昌.炙甘草汤临床应用研究进展[J].世界中医药，2020，15（11）：1662-1665.
[25] 牛利东，海江.炙甘草汤对冠心病不稳定型心绞痛患者血脂及血流变的影响[J].中国当代医药，2020，27（6）：153-155，166.
[26] 候爽，陈长军，杨博，等.蒺藜成分及主要药理作用研究进展[J].中国医药导报，2014，11（35）：156-159.
[27] 陈子珺，李庆生，李云森，等.防风与刺蒺藜的药理实验研究[J].中成药，2003，25（9）：737-739.
[28] 柳威，邓林华，祁东利，等.天麻及其有效成分的药理作用概述[J].中药药理与临床，2021，37（4）：240-244，12.
[29] 程阳阳，孔维佳.天麻素防治缺血性脑损伤的机制研究进展[J].中国医药导报，2020，17（6）：48-52.
[30] 许廷生，陆龙存，黄子冬，等.天麻有效成分的药理作用分析与临床应用研究进展[J].中医临床研究，2020，12（21）：133-135. |
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