基于数据挖掘和网络药理学探讨冠心病合并抑郁用药规律和作用机制

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Abstract Objective To analyze the medication rules of traditional Chinese medicine in the treatment of coronary heart disease complicated with depression by data mining, and to explore the potential mechanism of the core drugs. Methods CNKI, Wanfang Data, VIP, and China Biomedical Literature Service System were searched from January 2001 to July 2021 on the literature on the treatment of coronary heart disease complicated by depression with traditional Chinese medicine, the prescription database, was built and the traditional Chinese medicine inheritance assistance platform software was used to analyze the medication rules of prescriptions. The BATMAN-TCM traditional Chinese medicine analysis software was further used to analyze the genome encyclopedia pathway of the core drug compatibility to reveal the potential mechanism of action. Results A total of 70 prescriptions were included, involving 108 traditional Chinese medicines. The top six prescriptions were Bupleurum, Baishao, Chuanxiong, Salvia, Poria, and Suanzaoren. The four qi of the drug were mainly warm, and the five flavors were mostly bitter, acrid, and sweet. Eventually evolved to get eight new prescriptions. BATMAN-TCM analysis showed that there were 33 diseases with ≥four enriched targets in the combination of Bupleurum, Baishao, Chuanxiong, Poria, and Suanzaoren, and there were 37 biological pathways. Its mechanism of action might be through transient receptor potential channel, calcium signaling pathway, and cyclic guanosine monophosphate-protein kinase G signaling pathway in the treatment of coronary heart disease complicated with depression. Conclusion The combination of traditional Chinese medicine inheritance platform and network pharmacology is used to conduct data mining on the prescription rules and potential mechanism of Chinese medicine in the treatment of coronary heart disease complicated with depression, which can provide reference for clinical treatment and basic research of the disease.

Key words： Coronary heart disease Depression Medication rules Mechanism Soft-ware of tradition Chinese medicine inheritance assistance platform Network pharmacology

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	LI Dongfang1 HUANG Lexi2 HOU Jiqiu1 LI Yan3 ZHAO Haibin1

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LI Dongfang1 HUANG Lexi2 HOU Jiqiu1 LI Yan3 ZHAO Haibin1. Study on medication rule and action mechanism of coronary heart disease complicated with depression based on data mining and network pharmacology[J]. 中国医药导报, 2022, 19(22): 13-19.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I22/13

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