非小细胞肺癌患者组织中lncRNA MAGI2-AS3的表达及与病理参数和预后的关系

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Abstract Objective To investigate the expression of long non-coding RNA (lncRNA) membrane associated guanylate kinase, WW, and PDZ domain containing two-antisense RNA three (MAGI2-AS3) in non-small cell lung cancer (NSCLC) patient tissues and the relationship with pathological parameters and prognosis. Methods One hundred and three patients with NSCLC admitted to Danyang People’s Hospital Affiliated to Nantong University from August 2016 to August 2018 were selected. The expressions of lncRNA MAGI2-AS3 in cancer tissues and adjacent tissues were detected. The relationship between lncRNA MAGI2-AS3 expression and pathological parameters of NSCLC patients was analyzed. According to lncRNA MAGI2-AS3 expression level, patients were divided into high lncRNA MAGI2-AS3 expression group (≥ mean lncRNA MAGI2-AS3 expression level) and low lncRNA MAGI2-AS3 expression group (< mean lncRNA MAGI2-AS3 expression level). The three-year survival curve of NSCLC patients was drawn by using Kaplan-Meier method. Prognostic factors of NSCLC patients were analyzed by using multi-factor Cox regression. Results The expression of lncRNA MAGI2-AS3 in NSCLC tissues was lower than that in adjacent tissues, the difference was statistically significant (P < 0.05). There were significant differences in the expression of lncRNA MAGI2-AS3 in patients with different TNM stages and lymph node metastasis (P < 0.05). The median survival time of high lncRNA MAGI2-AS3 expression group (51 cases) was longer than that of low lncRNA MAGI2-AS3 expression group (52 cases), the difference was statistically significant (P < 0.05). Multivariate Cox regression analysis showed that degree of tumor differentiation, TNM stage, lymph node metastasis, and expression level of lncRNA MAGI2-AS3 were influencing factors for poor prognosis in patients with NSCLC (P < 0.05). Conclusion The low expression of lncRNA MAGI2-AS3 in NSCLC tissues is related to TNM stage, lymph node metastasis, and poor prognosis, which can be used as a prognostic indicator for NSCLC patients.

Key words： Non-small cell lung cancer Long non-coding RNA Membrane associated guanylate kinase, WW, and PDZ domain containing two-antisense RNA three Prognosis

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	YANG Guanghui1 PAN Huimin2 ZHA Lifen2 GU Jun1

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YANG Guanghui1 PAN Huimin2 ZHA Lifen2 GU Jun1. Expression of lncRNA MAGI2-AS3 in tissues of patients with non-small cell lung cancer and the relationship with pathological parameters and prognosis[J]. 中国医药导报, 2022, 19(20): 104-107.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I20/104

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