总胆红素及其与直接胆红素的比值对广泛期小细胞肺癌患者预后的预测价值

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Abstract Objective To evaluate the predictive value of total bilirubin to direct bilirubin and the ratio of the two in the prognosis of patients with extensive-stage small cell lung cancer (ES-SCLC). Methods A total of 83 ES-SCLC patients admitted to the 901st Hospital of the Joint Service Support Force of the Chinese People’s Liberation Army from January 2018 to July 2020 were selected as the research objects. Clinical data, biochemical tests, progression-free survival (PFS) and overall survival (OS) of patients upon admission were collected. Multivariate Cox regression was used to analyze the effect of bilirubin on the survival and prognosis of ES-SCLC patients, and the Kaplan-Meier method was used to evaluate the survival time. Results Total bilirubin and total bilirubin / direct bilirubin had predictive value for the survival and prognosis of ES-SCLC patients (P ＜ 0.05), and the best cut-off values were 12.3 μmol/L and 2.8, respectively; compared with patients in the low total bilirubin group (≤12.3 μmol/L), patients in the high total bilirubin group (＞12.3 μmol/L) had longer median PFS and OS (P ＜ 0.05); compared with patients in the low total bilirubin / direct bilirubin group (≤2.8), patients in the high total bilirubin / direct bilirubin group (＞2.8) had longer median PFS and OS (P ＜ 0.05); total bilirubin and total bilirubin / direct bilirubin were independent prognostic factors affecting ES-SCLC patients (P ＜ 0.05). Conclusion Total bilirubin level and total bilirubin / direct bilirubin level may be important prognostic factors of ES-SCLC, which can help determine the prognosis of patients.

Key words： Extensive-stage small cell lung cancer Total bilirubin Direct bilirubin Prognosis

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	CAI Xueqin1 XU Mingjing2 MA Huan1 LU Donghui1

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CAI Xueqin1 XU Mingjing2 MA Huan1 LU Donghui1. Predictive value of total bilirubin and its ratio to direct bilirubin in the prognosis of patients with extensive-stage small cell lung cancer#br#[J]. 中国医药导报, 2022, 19(2): 25-28,45.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I2/25

[1] Wang S，Zimmermann S，Parikh K，et al. Current Diagnosis and Management of Small-Cell Lung Cancer [J]. Mayo Clin Proc，2019，94（8）：1599-1622.
[2] Bernhardt EB，Jalal SI. Small Cell Lung Cancer [J]. Cancer Treat Res，2016，170：301-322.
[3] Rudin CM，Brambilla E，Faivre-Finn C，et al. Small-cell lung cancer [J]. Nat Rev Dis Primers，2021，7（1）：3.
[4] Jiang D，Shi J，Yuan M，et al. Levels of serum bilirubin in small cell lung cancer and non-small cell lung cancer patients [J]. Cell Mol Biol，2018，64（6）：71-76.
[5] 郑辉，杨焦峰，王伟娟.血清胆红素对肺癌患者病情发生发展的影响[J].河南大学学报：医学版，2020，39（4）：266-269.
[6] Zhang Y，Xu J，Lou Y，et al. Pretreatment direct bilirubin and total cholesterol are significant predictors of overall survival in advanced non-small-cell lung cancer patients with EGFR mutations [J]. Int J Cancer，2017，140（7）：1645-1652.
[7] Song Q，Wang B，Wang S，et al. Lower serum levels of bilirubin in the newly diagnosed lung cancer patients：A case-control study in China [J]. J Cancer Res Ther，2015， 11：C168-C172.
[8] 吴剑，冯杰，高艳红，等.肝功能，凝血因子及血常规检测在肺癌诊断与治疗中的应用价值[J].国际检验医学杂志，2020，41（14）：1706-1709.
[9] 蔚京京，范国权，李建强.呼吸系统炎症性疾病中胆红素水平的变化及意义[J].山西医科大学学报，2019，50（2）：69-73.
[10] 张宏伟，陈菊华.胆红素蛋白质测定在癌性胸腹腔积液中的表达及与病理细胞学的相关性研究[J].山西医药杂志，2019，48（5）：611-613.
[11] 费素娟.红细胞分布宽度及胆红素与胃癌临床特征的关系[J].胃肠病学和肝病学杂志，2021，30（2）：145.
[12] 牛兴杰，刘志慧，崔凤梅，等.系统炎症指标在乙型肝炎肝硬化及乙型肝炎病毒相关肝细胞癌进展中的预测价值[J].中国肝脏病杂志：电子版，2020，12（2）：1-9.
[13] 蔡春仙，付琪备，雷宇，等.C反应蛋白及直接胆红素作为肝细胞癌合并大血管侵袭的早期诊断指标[J].中华肝脏病杂志，2020，28（8）：692-698.
[14] Liu X，Meng QH，Ye Y，et al. Prognostic significance of pretreatment serum levels of albumin，LDH and total bilirubin in patients with non-metastatic breast cancer [J]. Carcinogenesis，2015，36（2）：243-248.
[15] Li N，Xu M，Cai MY，et al. Elevated serum bilirubin levels are associated with improved survival in patients with curatively resected non-small-cell lung cancer [J]. Cancer Epidemiol，2015，39（5）：763-768.
[16] 于溪，张彬彬，杨碧洁，等.血红蛋白和胆红素水平与广泛期小细胞肺癌预后的关系[J].中国医科大学学报，2017， 46（2）：112-115.
[17] Song YJ，Gao XH，Hong YQ，et al. Direct bilirubin levels are prognostic in non-small cell lung cancer [J]. Oncotarget，2018，9（1）：892-900.
[18] Cui J，Zhao H，Yi B，et al. Dexmedetomidine Attenuates Bilirubin-Induced Lung Alveolar Epithelial Cell Death In Vitro and In Vivo [J]. Crit Care Med，2015，43（9）：e356-e368.
[19] 蔚京京，陈晓娟，范国权，等.血清胆红素在儿童呼吸系统感染性疾病中的变化及临床意义[J].山西医科大学学报，2020，51（4）：74-78.
[20] 刘利东，马梓欣，林琪英，等.血清胆红素在肺癌患者中的抗氧化作用[J].实用医学杂志，2018，34（10）：1716-1719，1724.
[21] 李丹，孙冰，于斌，等.血清总胆红素与糖尿病微血管并发症的相关研究进展[J].中国医师进修杂志，2019，42（12）：1137-1141.
[22] 麻恒翔，李玲，谭于飞，等.CalliSpheres载药微球治疗中晚期非小细胞肺癌短期疗效分析[J].中国合理用药探索，2020，17（5）：53-57.
[23] 周阳，刘慧，张华，等.胆绿素还原酶在抗肿瘤治疗中作用的研究进展[J].癌症进展，2020，18（8）：7-10.
[24] 魏梦婷，孙曙光.血清胆红素在动脉粥样硬化中的研究进展[J].中国医学创新，2021，18（19）：184-188.
[25] 傅莉萍，王保法，洪郁芝.2型糖尿病患者尿酸排泄分数和血清胆红素相关性分析[J].中国现代医生，2021， 59（5）：16-19.
[26] Wei J，Zhao H，Fan G，et al. Bilirubin treatment suppresses pulmonary inflammation in a rat model of smoke-induced emphysema [J]. Biochem Biophys Res Commun，2015，465（2）：180-187.
[27] 罗美方.血清胆红素与尿酸检验在冠心病患者中的价值研究[J].中国医药科学，2020，10（7）：192-194.
[28] 蔚京京，赵卉，李建强.临床胆红素浓度与吸烟和慢性阻塞性肺疾病的关系[J].山西医科大学学报，2015（1）：49-51.