沉默信息调节因子1在术后认知功能障碍中保护作用的研究进展

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Abstract Postoperative cognitive dysfunction is particularly common after anesthesia, which has a serious impact on the quality of life and postoperative rehabilitation of patients, increasing the postoperative morbidity and mortality, and increasing the length of hospital stay and economic expenditure of patients. Silencing information regulator 1 (SIRT1) plays a crucial role in the pathogenesis of postoperative cognitive dysfunction, and plays a key protective role in neuroinflammatory response, oxidative stress, mitochondrial energy metabolism, endoplasmic reticulum stress, neuronal apoptosis, autophagy, and regulating nerve cell-related factors or proteins. In this paper, SIRT1 will be taken as the core to focus on the mechanism of its protective effect on cognitive impairment caused by anesthesia surgery, in order to provide some help for future scientific research in this field.

Key words： Silent information regulator 1 Postoperative cognitive dysfunction Neuroinflammation Endoplasmic reticulum stress Autophagy

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	QIN Xiaoyu1 WANG Chunai2

Cite this article:

QIN Xiaoyu1 WANG Chunai2. Research progress on the protective effect of silent information regulator 1 in postoperative cognitive dysfunction[J]. 中国医药导报, 2022, 19(16): 53-56.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I16/53

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