Ⅳ期肺腺癌患者ROS1基因状态与使用培美曲塞联合铂类方案化疗效果的关系

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Abstract Objective To investigate the relationship between ROS1 gene and efficiency of pemetrexed combined with platinum chemotherapy in patients with stage Ⅳ lung adenocarcinoma. Methods A total of 384 patients with stage Ⅳ lung adenocarcinoma treated in the Tumor Hospital Affiliated to Xinjiang Medical University from June 2015 to September 2018 were collected. According to ROS1 gene status, patients were divided into ROS1 positive group (32 cases) and ROS1 negative group (352 cases). All patients underwent ROS1 gene detection and received Pemetrexed combined with platinum chemotherapy. Relationships between objetive reposnse rate (ORR), disease control rate (DCR), progression free survival (PFS) and ROS1 gene status were analyzed. Results The ORR, DCR of ROS1 positive group were higher than ROS1 negative group (P ＜ 0.05). The survival rate of patients in ROS1 positive group was higher than that in ROS1 negative group (P ＜ 0.05). ROS1 gene was an influencing factor of death (HR = 0.590, 95%CI:0.403-0.863, P ＜ 0.05). Conclusion The first-line treatment of ROS1 positive patients with stage Ⅳ lung adenocarcinoma with Pemetrexed combined with platinum chemotherapy is better, and the time without disease progression is prolonged.

Key words： ROS1 Lung cancer Pemetrexed Chemotherapy Survival analysis

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	TAO Jie1 XUE Shuping2 MA Xiaomei3▲

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TAO Jie1 XUE Shuping2 MA Xiaomei3▲. Relationship between ROS1 gene and efficiency of pemetrexed combined with platinum chemotherapy in patients with stage Ⅳ lung adenocarcinoma#br#[J]. 中国医药导报, 2022, 19(11): 111-114,142.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I11/111

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