炎症因子及其相关信号通路在脊髓损伤调控机制中的研究进展

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Abstract Spinal cord injury (SCI) is a serious central nervous system injury. Secondary injury is an important cause of poor prognosis in SCI, and inflammation is one of the main secondary injury. A lot of literatures have shown that inflammation cytokines and related signaling pathways, such as nuclear factor (NF)-κB, JAK/STAT and MAPK/ERK, regulate the inflammtion after SCI. They play a key role in the development of SCI. In this review, inflammation cytokines are classified into proinflammatory and anti-inflammatory factors according to their effects. This review focuses on the key proinflammatory factors interleukin 6 (IL-6), tumor necrosis factor, and anti-inflammatory factors IL-4, IL-10 and reveals their roles in the process of SCI, so that researchers in related fields can understand the molecular mechanism of inflammation after SCI widely and deeply. Based on this, they may find better biological methods for the treatment of SCI.

Key words： Spinal cord injury Inflammtion cytokine Interleukin Tumor necrosis factor

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	Articles by authors
	SONG Jiefei1 ZHOU Yuxin1 ZHANG Yu1 WU Chengjie1
	2 MA Yong1
	2 GUO Yang1
	2

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SONG Jiefei1 ZHOU Yuxin1 ZHANG Yu1 WU Chengjie1,2 MA Yong1,2 GUO Yang1, et al. Research progress of inflammatory factors and their related signaling pathways in the regulation of spinal cord injury#br#[J]. 中国医药导报, 2021, 18(32): 38-41.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I32/38

[1] 祁健，张俊江，孟庆溪，等.脊髓损伤的病理变化及治疗进展[J].现代生物医学进展，2017，17（21）：4179-4183.
[2] 曾日祥，马勇，赖玉灵.急性脊髓损伤患者外周血hs-CRP、TNF-α、IL-6和IL-10的动态表达及临床意义[J].河北医药，2016，38（10）：1509-1511.
[3] 李柯柯，宗少晖.脊髓损伤中的免疫炎性细胞因子[J].中国组织工程研究，2015，19（53）：8646.
[4] Becher B，Spath S，Goverman J. Cytokine networks in neuroinflammation [J]. Nat Rev Immunol，2017，17（1）：49-59.
[5] Jia H，Ma H，Li Z，et al. Downregulation of LncRNA TUG1 Inhibited TLR4 Signaling Pathway-Mediated Inflammatory Damage After Spinal Cord Ischemia Reperfusion in Rats via Suppressing TRIL Expression [J]. J Neuropathol Exp Neurol，2019，78（3）：268-282.
[6] Chen J，Wang Z，Zheng Z，et al. Neuron and microglia/macrophage-derived FGF10 activate neuronal FGFR2/PI3K/Akt signaling and inhibit microglia/macrophages TLR4/NF-κB-dependent neuroinflammation to improve functional recovery after spinal cord injury [J]. Cell Death Dis，2017，8（10）：e3090.
[7] Tang R，Botchway B，Meng Y，et al. The Inhibition of Inflammatory Signaling Pathway by Secretory Leukocyte Protease Inhibitor can Improve Spinal Cord Injury [J]. Cell Mol Neurobiol，2020，40（7）：1067-1073.
[8] Tanaka T，Narazaki M，Kishimoto T. Interleukin （IL-6） Immunotherapy [J]. Cold Spring Harb Perspect Biol，2018， 10（8）：a028456.
[9] Yamauchi K，Osuka K，Takayasu M，et al. Activation of JAK/STAT signalling in neurons following spinal cord injury in mice [J]. J Neurochem，2006，96（4）：1060-1070.
[10] Yuan X，Wu Q，Wang P，et al. Intraspinal administration of interleukin-7 promotes neuronal apoptosis and limits functional recovery through JAK/STAT5 pathway following spinal cord injury [J]. Biochem Biophys Res Commun，2019，514（3）：1023-1029.
[11] Zhou YQ，Liu Z，Liu ZH，et al. Interleukin-6：an emerging regulator of pathological pain [J]. J Neuroinflammation，2016，13（1）：141.
[12] Madaro L，Passafaro M，Sala D，et al. Denervation-activated STAT3-IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis [J]. Nat Cell Biol，2018，20（8）：917-927.
[13] Sun L，Li M，Ma X，et al. Inhibition of HMGB1 reduces rat spinal cord astrocytic swelling and AQP4 expression after oxygen-glucose deprivation and reoxygenation via TLR4 and NF-κB signaling in an IL-6-dependent manner [J]. J Neuroinflammation，2017，14（1）：231.
[14] Kosmopoulos M，Christofides A，Drekolias D，et al. Critical Role of IL-8 Targeting in Gliomas [J]. Curr Med Chem，2018，25（17）：1954-1967.
[15] Leister I，Haider T，Mattiassich G，et al. Biomarkers in Traumatic Spinal Cord Injury-Technical and Clinical Considerations：A Systematic Review [J]. Neurorehabil Neural Repair，2020，34（2）：95-110.
[16] Palomino DC，Marti LC. Chemokines and immunity [J]. Einstein （Sao Paulo），2015，13（3）：469-473.
[17] Kany S，Vollrath JT，Relja B. Cytokines in Inflammatory Disease [J]. Int J Mol Sci，2019，20（23）：6008.
[18] Zelová H，Ho?觢ek J. TNF-α signalling and inflammation：interactions between old acquaintances [J]. Inflamm Res，2013，62（7）：641-651.
[19] Idriss HT，Naismith JH. TNF alpha and the TNF receptor superfamily：structure-function relationship（s） [J]. Microsc Res Tech，2000，50（3）：184-195.
[20] Jorge A，Taylor T，Agarwal N，et al. Current Agents and Related Therapeutic Targets for Inflammation After Acute Traumatic Spinal Cord Injury [J]. World Neurosurg，2019， 132：138-147.
[21] Grebe A，Hoss F，Latz E. NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis [J]. Circ Res，2018，122（12）：1722-1740.
[22] Mendiola AS，Cardona AE. The IL-1β phenomena in neuroinflammatory diseases [J]. J Neural Transm （Vienna），2018，125（5）：781-795.
[23] Malik A，Kanneganti TD. Inflammasome activation and assembly at a glance [J]. J Cell Sci，2017，130（23）：3955-3963.
[24] Kelley N，Jeltema D，Duan Y，et al. The NLRP3 Inflammasome：An Overview of Mechanisms of Activation and Regulation [J]. Int J Mol Sci，2019，20（13）：3328.
[25] Kwiecien JM，Dabrowski W，D?諭browska-Bouta B，et al. Prolonged inflammation leads to ongoing damage after spinal cord injury [J]. PLoS One，2020，15（3）：e226584.
[26] Xuan W，Qu Q，Zheng B，et al. The chemotaxis of M1 and M2 macrophages is regulated by different chemokines [J]. J Leukoc Biol，2015，97（1）：61-69.
[27] Gadani SP，Cronk C，Norris GT，et al. IL-4 in the brain：a cytokine to remember [J]. J Immunol，2012，189（9）：4213-4219.
[28] Gour N，Wills-Karp M. IL-4 and IL-13 signaling in allergic airway disease [J]. Cytokine，2015，75（1）：68-78.
[29] Lima R，Monteiro S，Lopes JP，et al. Systemic Interleukin-4 Administration after Spinal Cord Injury Modulates Inflammation and Promotes Neuroprotection [J]. Pharmaceuticals （Basel），2017，10（4）：83.
[30] Kobashi S，Terashima T，Katagi M，et al. Transplantation of M2-Deviated Microglia Promotes Recovery of Motor Function after Spinal Cord Injury in Mice [J]. Mol Ther，2020，28（1）：254-265.
[31] Kiguchi N，Kobayashi Y，Saika F，et al. Peripheral interleukin-4 ameliorates inflammatory macrophage-dependent neuropathic pain [J]. Pain，2015，156（4）：684-693.
[32] Saraiva M，Vieira P，O’Garra A. Biology and therapeutic potential of interleukin-10 [J]. J Exp Med，2020，217（1）：e20190418.
[33] Hellenbrand DJ，Reichl KA，Travis BJ，et al. Sustained interleukin-10 delivery reduces inflammation and improves motor function after spinal cord injury [J]. J Neuroinflammation，2019，16（1）：93.
[34] Moore KW，de Waal MR，Coffman RL，et al. Interleukin-10 and the interleukin-10 receptor [J]. Annu Rev Immunol，2001，19：683-765.
[35] Chen Y，Wang D，Cao S，et al. Association between Serum IL-37 and Spinal Cord Injury：A Prospective Observational Study [J]. Biomed Res Int，2020，2020：6664313.
[36] Coll-Miró M，Francos-Quijorna I，Santos-Nogueira E，et al. Beneficial effects of IL-37 after spinal cord injury in mice [J]. Proc Natl Acad Sci U S A，2016，113（5）：1411-1416.
[37] Amo-Aparicio J，Sanchez-Fernandez A，Li S，et al. Extracellular and nuclear roles of IL-37 after spinal cord injury [J]. Brain Behav Immun，2021，91：194-201.
[38] Cavalli G，Dinarello CA. Suppression of inflammation and acquired immunity by IL-37 [J]. Immunol Rev，2018， 281（1）：179-190.
[39] Hamidzadeh K，Christensen SM，Dalby E，et al. Macrop-hages and the Recovery from Acute and Chronic Inflammation [J]. Annu Rev Physiol，2017，79：567-592.
[40] Leal-Filho MB. Spinal cord injury：From inflammation to glial scar [J]. Surg Neurol Int，2011，2：112.
[41] Matsuda M，Huh Y，Ji RR. Roles of inflammation，neurogenic inflammation，and neuroinflammation in pain [J]. J Anesth，2019，33（1）：131-139.