脑缺血/再灌注损伤后线粒体结构与功能稳态失衡机制的研究进展

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Abstract [Abstract] Ischemic stroke is a disease characterized by high mortality, high disability rate and low cure rate. Ischemia/reperfusion injury caused by blood flow recanalization after stroke will cause more serious damage to brain tissue, the destruction of mitochondrial structure and function homeostasis is one of the main pathological links. The changes of mitochondrial structure and function after cerebral ischemia / reperfusion injury have great significance to promote the neuronal protection of ischemic brain injury. In recent years, the research on mitochondrial homeostasis imbalance such as mitochondrial oxidative stress, permeability transition pore, calcium overload and mitochondrial autophagy has become more theoretical and systematic, and the interaction mechanism with cerebral ischemia / reperfusion injury has become more clear. This paper summarizes and discusses the specific mechanism of mitochondrial structural and functional homeostasis imbalance after cerebral ischemia / reperfusion injury, in order to provide new ideas and methods for the clinical application of ischemic stroke.

Key words： Cerebral ischemia / reperfusion injury Mitochondria Functional homeostasis Review

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	WU Dan1 QI Zhongwen1 ZHANG Wei1 MA Yan2

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WU Dan1 QI Zhongwen1 ZHANG Wei1 MA Yan2. Research progress on the mechanism of mitochondrial structural and functional homeostasis imbalance after cerebral ischemia / reperfusion injury#br#[J]. 中国医药导报, 2021, 18(31): 42-45，66.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I31/42

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