Research progress in pharmacogenomics of anesthesia and perioperative period management in enhanced recovery after surgery
MA Lina1,2 GUO Haiyun2 MA Yumei1,2 NIE Huang2▲
1.Graduate School, Air Force Medical University, Shaanxi Province, Xi’an 710000, China;
2.Department of Anesthesia and Perioperative Period Medicine, Xijing Hospital of Air Force Medical University, Shaanxi Province, Xi’an 710000, China
Abstract Individualized management of standardized clinical pathways is one of the goals of enhanced recovery after surgery, and drug gene polymorphism is an important genetic factor that causes individual differences in drug response. This review discusses the pharmacogenomics of drugs commonly used during anesthesia and perioperative period. Focusing on analgesics, introduces the gene polymorphism and clinical application of opioid analgesics and non-steroidal anti-inflammatory drugs, and also involves the common drugs involved in anesthesia and perioperative period management such as intravenous anesthesia drugs, inhalation anesthesia drugs, neuromuscular blockers, and antiemetic drugs. The effectiveness and feasibility of using pharmacogenomics to guide individual medicine are demonstrated, and the future research direction is discussed.
MA Lina1,2 GUO Haiyun2 MA Yumei1,2 NIE Huang2▲. Research progress in pharmacogenomics of anesthesia and perioperative period management in enhanced recovery after surgery[J]. 中国医药导报, 2021, 18(27): 39-42.
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