唑来膦酸治疗骨质疏松不良反应影响因素及防治的研究进展

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Abstract Osteoporosis is one of the global health problems, which seriously affects the health and quality of life of patients. Bisphosphonates are currently the first-line drugs recommended by the international community for the treatment of osteoporosis. As the third-generation bisphosphonates, Zoledronic Acid is widely used in clinical practice because of its strong anti-bone resorption effect and effective relief of osteoporosis symptoms. However, with the deepening of research, more and more medical workers have pointed out in their reports that there are many kinds of adverse reactions when using Zoledronic Acid, and the incidence of acute phase reaction, osteonecrosis of the jaw, ocular complications, kidney injury, hypocalcemia and other adverse reactions is higher or the symptoms are more serious in clinical practice. In this paper, the mechanism, adverse reactions and their influencing factors, prevention and control of adverse reactions of Zoledronic Acid in the treatment of osteoporosis are reviewed to provide a reference for clinical use of Zoledronic Acid.

Key words： Zoledronic Acid Osteoporosis Adverse reactions Influencing factors Prevention and control

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	WU Hongliang1* ZHENG Sihang1* JING Shengjie2 XING Ruida3 GONG Helong1 TIAN Ye1

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WU Hongliang1* ZHENG Sihang1* JING Shengjie2 XING Ruida3 GONG Helong1 TIAN Ye1. Research progress on influencing factors and prevention of adverse reactions of Zoledronic Acid in the treatment of osteoporosis[J]. 中国医药导报, 2021, 18(23): 38-42.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I23/38

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