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| Regularity of traditional Chinese medicine in the treatment of cough variant asthma |
| WU Qing1 MA Xiaomeng1 LUO Yinhe1▲ WANG Mengqing2▲ |
| 1.College of Integrated Traditional Chinese and Western Medicine, Hu’nan University of Chinese Medicine, Hu’nan Province, Changsha 410208, China; 2.Department of Pediatric, the First Hospital of Hu’nan University of Chinese Medicine, Hu’nan Province, Changsha 410007, China |
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Abstract Objective To explore the regularity of traditional Chinese medicine in the treatment of cough variant asthma. Methods With traditional Chinese medicine and cough variant asthma as the main topics, the literatures collected from CNKI since inception to June 2020 were searched. The prescriptions recorded in literature were collected and a database was established. Excel 2003 and SPSS Modeler 18.0 software were used to statistically analyze the frequency, nature and flavour, channel tropism, efficacy and correlation degree of the included traditional Chinese medicine. Results A total of 55 journal articles that met the standards were included, containing 103 traditional Chinese medicines, with a total frequency of 637 times. Among the 103 traditional Chinese medicines included, there were 20 kinds of traditional Chinese medicines with frequency ≥ten, and the drugs with the highest word frequency were liquorice root, ephedra, cicada slough, bitter apricot seed, stiff silkworm, etc. The proportion of drugs in the “four nature of drugs” from large to small was cold, warm, calm, cool, hot. The proportion of drugs in the “five flavours” from large to small is bitter, sweet, pungent, sour, salty, astringent and tasteless. The frequency of drug channelization was lung, spleen, stomach, liver, heart, etc. Reducing phlegm, relieving cough and relieving asthma drugs, tonifying deficiency drugs, heat-clearing drugs, relieving exterior disorder drugs, suppressing hyperactive liver for calming endogenous wind drugs were the most common in the efficacy classification. Apriori association rule results showed that there were 14 combinations of drug pairs with the highest association strength, and reducing phlegm, relieving cough and relieving asthma drugs were the main ones, and most of them were used in combination with tonifying deficiency drugs. Conclusion Freeing lung and relieving asthma, relieving cough and relieving asthma, dispelling pathogenic wind for resolving convulsion are the core therapeutic principles for clinical treatment of cough variant asthma.
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