电项针联合药物治疗脑小血管病认知功能障碍的效果

Abstract
Figure/Table
References (29)
Related Citation (15)

Download: PDF (752 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract of Acupuncture and Massage, Heilongjiang University of Chinese Medicine Department of Acupuncture, Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China; 2.Teaching and Research Section of Massage, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150036, China
[Abstract] Objective To investigate the effect of electric nape acupuncture combined with drugs on the cognitive dys function of patients with cerebral small vessel disease (CSVD). Methods A total of 72 patients with CSVD admitted to the outpatient department and ward of Second Affiliated Hospital of Heilongjiang University of Chinese Medicine from April 2018 to October 2020 were selected and they were divided into control group and treatment group by random number table method, with 36 patients in each group. The control group received oral medicine, acupuncture, symptomatic basic treatment. The treatment group was combined with electric nape acupuncture therapy on the basis of the control group, and both groups were treated for eight weeks. The Montreal cognitive assessment scale (MOCA) and the mini-mental state examination (MMSE) were used to assess the two groups before, two weeks and eight weeks after treatment, respectively. Results Of the 72 patients, 69 cases were actually observed and three cases were abscission. Among them, 35 cases in the control group and 34 cases in the treatment group completed observation. There were statistically significant differences in comparison between groups, time point comparison and interaction (P ＜ 0.05). Comparison within groups: MoCA and MMSE scores of the two groups after eight weeks of treatment were significantly higher than those before and after two weeks of treatment, the differences were statistically significant (all P ＜ 0.05). There were no significant differences in MoCA and MMSE scores between the two groups before treatment and two weeks after treatment (P ＞ 0.05). Comparison between groups: there were no significant differences in MoCA and MMSE scores between the two groups before treatment and two weeks after treatment (P ＞ 0.05). After eight weeks of treatment, MoCA and MMSE scores in the treatment group were significantly higher than those in the control group, and the differences were statistically significant (all P ＜ 0.05). Conclusion Electric nape acupuncture therapy can improve the MMSE and MoCA scores of patients with cognitive dysfunction of CSVD, and improve the cognitive function, and the longer the course of treatment, the better the benefit.

Key words： Cerebral small vessel disease Cognitive function Electric nape acupuncture therapy Mini-mental state examination Montreal cognitive assessment scale

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LIU Huihui1 JIANG Wei2▲ SUN Zhongren1 CAO Yi1 JIAO Chuanxu1 ZHU Jinyi1 ZHANG Wenze1 ZHONG Sitong1

Cite this article:

LIU Huihui1 JIANG Wei2▲ SUN Zhongren1 CAO Yi1 JIAO Chuanxu1 ZHU Jinyi1 ZHANG Wenze1 ZHONG Sitong1. Effect of electric nape acupuncture combined with drugs on cognitive dysfunction of cerebral small vessel disease[J]. 中国医药导报, 2021, 18(15): 158-161,174.

URL:

https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I15/158

[1] 袁俊亮，李讙婷，王双坤.脑小血管病与认知功能障碍[J]. 中华行为医学与脑科学杂志，2018，27（3）：285-288.
[2] 王雅楠，牛雪芬，范少凯，等.缺血性脑小血管病患者凝血标志物及同型半胱氨酸与血管性认知障碍的相关性[J].中华老年心脑血管病杂志，2020，22（3）；281-284.
[3] 彭丹涛，邵文.脑小血管病相关认知功能障碍中国诊疗指南（2019）[J].阿尔茨海默病及相关病杂志，2019，2（3）：405-407.
[4] 韦佳，张毅，张惠琴，等.可逆性胆碱酯酶抑制剂治疗脑小血管病所致认知功能障碍的电生理研究[J].国神经免疫学和神经病学杂志，2016，23（1）：34-37.
[5] 刘斐雯，郑国华，陶静，等.针刺综合疗法治疗脑卒中后认知障碍的研究进展[J].中国康复，2016，31（5）：384-386.
[6] 李淑芝，张茜，卢金荣，等.头穴透刺治疗对血管性痴呆患者血清TNF-α、IL-1β的影响[J].中国中医药科技，2017， 24（6）：679-681.
[7] 刘兰群，李惠兰，陈之罡，等.电针头部“神”穴对脑卒中后认知功能障碍的效果[J].中国康复理论与实践，2015， 21（5）：575-578.
[8] 徐建国，彭从斌.电针治疗遗忘型轻度认知功能障碍的临床研究[J].中华全科医学，2017，15（3）：393－396.
[9] 中华医学会神经病学分会痴呆与认知障碍学组写作组，中国阿尔茨海默病协会.中国痴呆与认知障碍诊治指南：轻度认知障碍的诊断和治疗[J].中华医学杂志，2016，90（41）：2887-2893.
[10] 胡建琴，沈双.脑小血管病的影像学表现与认知功能障碍的关系[J].中国现代医生，2017，55（35）：94-97.
[11] 张道龙.美国精神障碍诊断与统计手册第5版[M].北京：北京大学出版社，2015：135-138.
[12] 王华，杜元灏.针灸学[M].北京：中国中医药出版社，2012：64，88，89，91，94.
[13] 赵旭.奥拉西坦辅助治疗缺血性脑卒中后认知功能障碍的疗效观察[J].中国现代药物应用，2018，12（6）：115-116.
[14] Haffner C，Malik R，DichgansM. Genetic factors in cerebral small vessel disease and their impact on stroke and dementia [J]. J Cereb Blood Flow Metab，2016，36（1）：158-171.
[15] 刘国荣，潘晓华，刘秀珍，等.炎症小体NLRP3相关炎症因子IL-1β、IL-18与脑小血管病相关因素[J].脑与神经疾病杂志，2019，27（3）：153-157.
[16] 马娜，刘远洪，梁金花，等.血管性痴呆患者血清IGF-1、Lp-PLA2、NLRP3的变化及与细胞因子的相关性研究[J].实验与检验医学，2018，36（4）：585-587.
[17] 刘恋，李梦，罗鹏，等.高密度脂蛋白与痴呆症研究进展[J].中国老年学杂志，2020，40（9）：1995-1999.
[18] 刘长英，周莉，董兴鲁，等.益气活血逐瘀法治疗脑小血管病的理论探析[J].世界中医药，2021，16（1）：134-136.
[19] Inzitari D，Pracucci G，Poggesi A，et al. Changes in angees in white mat-ter as determinant of globl functional decline in older inde-pendents：three year follow-up of LADIS（leuko-araiosis and disability）study cohort [J]. BMJ，2009，339：b2477.
[20] 姜广亚，娄季宇，杨霄鹏，等.盐酸多奈哌齐联合高压氧治疗血管性认知障碍疗效观察[J].中国实用神经疾病杂志，2019，22（22）：2498-2503.
[21] 刘四平，袁昆雄.盐酸多奈哌齐治疗阿尔茨海默病的疗效观察[J].吉林医学，2020，41（1）：137-138.
[22] 霍俊婷，宋士萍，李薇，等.叶酸和维生素B12辅助治疗对阿尔茨海默病患者认知功能及血清细胞因子、神经递质的影响[J].疑难病杂志，2019，18（2）：123-126.
[23] 赵亚洲，方璟，涂军，等.盐酸多奈哌齐治疗阿尔茨海默症的临床疗效观察[J].当代医学，2019，25（36）：170-172.
[24] 孙嫄，黄颖，陈巍巍，等.丁苯酞联合多奈哌齐改善脑小血管病者的认知功能[J].神经损伤与功能重建，2019， 14（5）：253-255.
[25] 高维滨.高维滨针刺十绝：神经病针刺新疗法[M].北京：中国医药科技出版社，2019：47-49.
[26] 滕秀英，周志伟.电项针对椎-基底动脉系统短暂性脑缺血发作性眩晕的影响[J].中医药信息，2013，30（2）：80-82.
[27] 陈伊，刘勇，王鸿波，等.电针项部六穴对后循环缺血患者脑干诱发电位的影响[J].针灸临床杂志，2016，32（6）：31-33.
[28] 刘勇，孙嘉婧，陈伊.电项针对后循环缺血大鼠模型脑干听觉诱发电位影响的实验研究[J].针灸临床杂志，2019， 35（1）： 64-67.
[29] 陈晶，胡新颖，刘勇，等.电项针对全脑缺血VD模型大鼠PI3K/AKT/GSK-3β信号通路的影响[J].世界中西医结合杂志，2018，13（2）：200-203，288.