调经促孕针刺法治疗早发性卵巢功能不全行体外受精-胚胎移植术患者的效果

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Abstract Objective To observe the effect of regulating menstruation and promoting pregnancy acupuncture in the treatmen of patients with premature ovarian insufficiency (POI) undergoing in vitro fertilization and embryo transfer (IVF-ET). Methods From November 2018 to October 2020, Eighty POI patients who admitted to Department of Acupuncture and Moxibustion, Shenzhen Traditional Chinese Medicine Hospital and Department of Chinese Medicine, Shenzhen Maternal ＆ Child Healthcare Hospital Affiliated to Southern Medical University and planned to undergo IVF-ET were selected as the research subjects. They were divided into the acupuncture group and the control group according to the random number table method, with 40 cases in each group. All patients were preconditioned artificially for three months, followed by an antagonist regimen for ovulation induction. The control group was not given any acupuncture treatment in the whole process, while the acupuncture group was given acupuncture therapy. The sex hormone levels, gonadotropin use between the two groups were compared before and after treatment; the number of mature follicles (≥1.8 cm), endometrial thickness, the level of estradiol (E2) and the number of eggs obtained on injection human chorionic gonadotropin (hCG) day. Results Before and after treatment, there were no significant differences in the levels of basic follicle-stimulating hormone (bFSH), basic luteinizing hormone (bLH), basic estradiol (bE2) and antimullerian hormone (AMH) between the two groups (P > 0.05). After treatment, the levels of bFSH and bLH in both groups were lower than those before treatment, and the differences were highly statistically significant (all P < 0.01). There were no significant differences in bE2 and AMH between the two groups after treatment and before treatment (P > 0.05). The amount of Urinary Follicle-Stimulating Hormone for injection, the starting amount and total use time in the acupuncture group were lower than those in the control group, and the differences were highly statistically significant (all P < 0.01); On hCG day, the number of mature follicles ≥1.8 cm, endometrial thickness, the proportion of A+B type endometrium and the number of eggs obtained were higher than those in the control group, and the differences were statistically significant (P < 0.05 or P < 0.01); the level of E2 in the acupuncture group was higher than that in the control group, and the difference was statistically significant (P < 0.05). Conclusion Regulating menstruation and promoting pregnancy acupuncture can improve the sensitivity to gonadotropin, increase the thickness of endometrium, improve the ovarian ovulation function and endometrial receptivity.

Key words： Premature ovarian insufficiency Acupuncture Regulating menstruation and promoting pregnancy In vitro fertilization embryo transfer Effect comparison

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	ZHUO Yuanyuan1 HUANG Xingxian1 HUANG Yishan1 WU Jiaman2

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ZHUO Yuanyuan1 HUANG Xingxian1 HUANG Yishan1 WU Jiaman2. Effect of regulating menstruation and promoting pregnancy acupuncture in the treatment of patients with premature ovarian insufficiency undergoing in vitro fertilization and embryo transfer[J]. 中国医药导报, 2021, 18(15): 125-128,132.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I15/125

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