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| Research progress on the mechanism of damage of asymptomatic hyperuricemia to vascular endothelial function |
| WU Xiaowen1 ZHU Xiaolin2 YANG Yali2 YIN Liping2 |
1.Graduate School, Nanjing University of Chinese Medicine, Jiangsu Province, Nanjing 210000, China;
2.Department of Nephrology, the Second Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province, Nanjing 210017, China |
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Abstract Asymptomatic hyperuricemia is a metabolic disorder characterized by elevated levels of serum uric acid. Elevated uric acid stimulates the inflammatory process, promotes oxidative stress, reduces nitric oxide bioavailability, activates the renin-angiotensin system, induces changes in mitochondrial function, and causes endothelial dysfunction, accelerating the progression of chronic kidney disease, cardiovascular system disease, metabolic disease, and other chronic diseases. This article elaborates on the mechanism of high-level uric acid damage to vascular endothelium, in order to provide new ideas for clinical diagnosis and treatment.
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[1] 封番番，张蓓，周连锁，等.无症状高尿酸血症的诊治和管理[J].江苏医药，2021，47（11）：1182-1185.
[2] Zhu B，Wang Y，Zhou W，et al. Trend dynamics of gout prevalence among the Chinese population，1990-2019：a joinpoint and age-period-cohort analysis [J]. Front Public Health，2022，10：1008598.
[3] Tang J，Liu K，Eshak ES，et al. Association between serum uric acid and impaired endothelial function：the circulatory risk in communities study [J]. J Atheroscler Thromb，2022， 29（10）：1534-1546.
[4] 刘维.痛风及高尿酸血症中西医结合诊疗指南[J].中医杂志，2023，64（1）：98-106.
[5] Ambrosino P，Bachetti T，D’Anna SE，et al. Mechanisms and clinical implications of endothelial dysfunction in arterial hypertension [J]. J Cardiovasc Dev Dis，2022，9（5）：136.
[6] Xu S，Ilyas I，Little PJ，et al. Endothelial dysfunction in athe- rosclerotic cardiovascular diseases and beyond：from mechanism to pharmacotherapies [J]. Pharmacol Rev，2021，3（73）： 924-967.
[7] Yanai H，Adachi H，Hakoshima M，et al. Molecular biological and clinical understanding of the pathophysiology and treatments of hyperuricemia and its association with metabolic syndrome，cardiovascular diseases and chronic kidney disease [J]. Int J Mol Sci，2021，22（17）：9221.
[8] Borghi C，Agabiti-Rosei E，Johnson RJ，et al. Hyperuricaemia and gout in cardiovascular，metabolic and kidney disease [J]. Eur J Intern Med，2020，80：1-11.
[9] George J，Carr E，Davies J，et al. High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid [J]. Circulation，2006，114（23）：2508-2516.
[10] 张城林，何蕾，王力，等.内皮功能障碍的发生机制[J].中国科学：生命科学，2022，52（5）：691-698.
[11] Wang M，Lin X，Yang X，et al. Research progress on related mechanisms of uric acid activating NLRP3 inflammasome in chronic kidney disease [J]. Ren Fail，2022，44（1）：615-624.
[12] Riaz M，Al Kury LT，Atzaz N，et al. Carvacrol alleviates hyperuricemia-induced oxidative stress and inflammation by modulating the NLRP3/NF-κB pathwayt [J]. Drug Des Devel Ther，2022，16：1159-1170.
[13] Kim S，Lee KS，Choi S，et al. NF-κB-responsive miRNA-31-5p elicits endothelial dysfunction associated with preeclampsia via down-regulation of endothelial nitric-oxide synthase [J]. J Biol Chem，2018，293（49）：18989-19000.
[14] Cuhlmann S，Van der Heiden K，Saliba D，et al. Disturbed blood flow induces RelA expression via c-Jun N-terminal kinase 1：a novel mode of NF-κB regulation that promotes arterial inflammation [J]. Circ Res，2011，108（8）：950-959.
[15] Jiang M，Ding H，Huang Y，et al. Shear stress and metabolic disorders-two sides of the same plaque [J]. Antioxid Redox Signal，2022，37（10/12）：820-841.
[16] Liang WY，Zhu XY，Zhang JW，et al. Uric acid promotes chemokine and adhesion molecule production in vascular endothelium via nuclear factor-kappa B signaling [J]. Nutr Metab Cardiovasc Dis，2015，25（2）：187-194.
[17] Liu YR，Wang JQ，Li J. Role of NLRP3 in the pathogenesis and treatment of gout arthritis [J]. Front Immunol，2023， 14：1137822.
[18] Alberts BM，Bruce C，Basnayake K，et al. Secretion of IL-1β from monocytes in gout is redox independent [J]. Front Immunol，2019，29：10-70.
[19] Magnacca S，Costanzo S，Curtis AD，et al. Determinants of serum uric acid levels in an adult general population：results from the Moli-sani Study [J]. Clin Rheumatol，2020， 40（3）：857-865.
[20] Vaduganathan M，Greene SJ，Ambrosy AP，et al. Relation of serum uric acid levels and outcomes among patients hospitalized for worsening heart failure with reduced ejection fraction （from the efficacy of vasopressin antagonism in heart failure outcome study with tolvaptan trial） [J]. Am J Cardiol，2014，114（11）：1713-1721.
[21] Maruhashi T，Hisatome I，Kihara Y，et al. Hyperuricemia and endothelial function：from molecular background to clinical perspectives [J]. Atherosclerosis，2018，278：226-231.
[22] Gherghina ME，Peride I，Tiglis M，et al. Uric acid and oxidative stress-relationship with cardiovascular，metabolic，and renal impairment [J]. Int J Mol Sci，2022，23（6）：3188.
[23] Janaszak-Jasiecka A，P?覥oska A，Wierońska JM，et al. Endothelial dysfunction due to eNOS uncoupling：molecular mechanisms as potential therapeutic targets [J]. Cell Mol Biol Lett，2023，28：1-21.
[24] Yu MA，Sanchez Lozada LG，Johnson RJ，et al. Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction [J]. J Hypertens，2010，28（6）：1234-1242.
[25] Hong Q，Wang L，Huang Z，et al. High concentrations of uric acid and angiotensin Ⅱ act additively to produce endo- thelial injury [J]. Mediators Inflamm，2020，2020：8387654.
[26] Liu J，Chen L，Yuan H，et al. Survey on uric acid in Chinese subjects with essential hypertension （SUCCESS）：a nationwide cross-sectional study [J]. Ann Transl Med，2021， 9（1）：27.
[27] Sun M，Hines N，Scerbo D，et al. Allopurinol lowers serum urate but does not reduce oxidative stress in CKD [J]. Antioxidants（Basel），2022，11（7）：1297.
[28] Muraya N，Kadowaki D，Miyamura S，et al. Benzbromarone attenuates oxidative stress in angiotensin Ⅱ- and salt-induced hypertensive model rats [J]. Oxid Med Cell Longev，2018，2018：7635274.
[29] Dera AA，Rajagopalan P，Alfhili MA，et al. Thymoquinone attenuates oxidative stress of kidney mitochondria and exerts nephroprotective effects in oxonic acid-induced hyperuricemia rats [J]. Biofactors，2020，46（2）：292-300.
[30] Sánchez-Lozada LG，Lanaspa MA，Cristóbal-García M，et al. Uric acid-induced endothelial dysfunction is associated with mitochondrial alterations and decreased intracellular ATP concentrations [J]. Nephron Exp Nephrol，2012，121（3-4）：e71-e78.
[31] Saito Y，Tanaka A，Node K，et al. Uric acid and cardiovascular disease：a clinical review [J]. J Cardiol，2021，78（1）：51-57. |
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