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| Stiff-person syndrome: a report of two cases and literatures analysis |
| TONG Weifang1 XU Mingming2 WANG Xijin1 |
1.Department of Neurology, Tongji Hospital of Tongji University, Shanghai 200065, China;
2.Department of Neurology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University of Medicine, Shanghai 200092, China |
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Abstract Stiff-person syndrome (SPS) is characterized by fluctuating, progressive stiffness of the trunk and proximal limbs, accompanied by painful spasticity. With the progression of the disease, SPS patients are prone to permanent skeletal abnormalities, eventually leading to inability to walk and disability. However, most patients can be improved by medical treatment in the early stage. Therefore, early diagnosis and treatment are essential to prevent or delay the progression of the disease. However, the clinical manifestations of SPS are complex and variable, which brings great challenges to medical workers. Therefore, doctors need to further strengthen the study of relevant theoretical knowledge and improve the understanding of this disease. This paper reports the medical records of two cases with SPS treated in Tongji Hospital of Tongji University in 2023. Among them, one was SPS patient with Hashimoto thyroiditis, and the other was SPS patient with thymoma. By discussing the clinical characteristics of the two special SPS cases, it is helpful to improve the early recognition and diagnosis of doctor and reduce misdiagnosis and mistreatment.
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