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| Correlation analysis of Notch signaling pathway related molecules, procalcitonin， and serum 25-hydroxyvitamin D3 expression and prognosis in children with community-acquired pneumonia |
| LI Xiaona1 ZHAO Hemeng1 ZHOU Jinjin1 WANG Juan1▲ MENG Meng2 DING Jie3 |
1.Department of Pediatric Internal Medicine, the First People’s Hospital of Lianyungang, Jiangsu Province, Lianyungang 222000, China;
2.Department of Pediatrics, the Affiliated Hospital of Xuzhou Medical University, Jiangsu Province, Xuzhou 221006, China;
3.Department of Pediatrics, Yancheng NO.1 People’s Hospital, Jiangsu Province, Yancheng 224004, China |
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Abstract Objective To study the relationship between Notch signaling pathway related molecules, procalcitonin (PCT)， and serum 25-hydroxyvitamin D3 (25 [OH] D3) expression, and prognosis in children with community-acquired pneumonia (CAP). Methods The clinical data of 160 children with CAP admitted to the First People’s Hospital of Lianyungang, Jiangsu Province from January 2018 to January 2021 were retrospectively analyzed. The patients were followed up for 60 days after treatment and they were divided into good prognosis group and poor prognosis group according to clinical symptoms and imaging results. The expression of relevant basic data and laboratory indicators (total cholesterol [TC], triglyceride [TG], high density lipoprotein cholesterol [HDL-C], PCT, and 25 [OH] D3), and Notch signaling pathway related molecules (Notch1, Notch2, Notch3, Notch4, Jagged1, DLL1, and DLL3) were compared between two groups; the risk factors of poor prognosis in children with CAP were analyzed; the predictive value of Notch1, Notch3, Jagged1, DLL1, PCT, and 25[OH] D3 for poor prognosis in children with CAP was analyzed. Results A total of 31 out of 160 children with CAP had poor prognosis. There were no significant differences in gender, age, TC, TG, HDL-C, Notch2, Notch4, and DLL3 between two groups (P＞0.05); Not- ch1, Notch3, Jagged1, DLL1, and PCT level in poor prognosis group were higher than those in good prognosis group, and 25 [OH] D3 level was lower than that in good prognosis group (P＜ 0.05). Notch1, Notch3, Jagged1, DLL1, PCT were risk factors for poor prognosis of children with CAP (OR＞1, P＜0.05); 25 [OH] D3 was protective factor for poor prognosis of children with CAP (OR＜1, P＜0.05). The areas under the curve of Notch1, Notch3, Jagged1, DLL1, PCT, and 25 [OH] D3 predicting poor prognosis were 0.830, 0.883, 0.935, 0.934, 0.708, and 0.867, respectively. Conclusion The prognosis of children with CAP is influenced by many factors, and is closely related to Notch1, Notch3, Jagged1, DLL1, PCT, and 25 [OH] D3, which should be paid close attention to clinically.
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[1] Manikam L，Schilder A，Lakhanpaul M，et al. Respiratory tract infection-related healthcare utilisation in children with Down’s syndrome [J]. Infection，2020，48（3）：403-410.
[2] Hueniken K，Aglipay M，Birken C，et al. Effect of High-Dose Vitamin D Supplementation on Upper Respiratory Tract Infection Symptom Severity in Healthy Children [J]. Pediatr Infect Dis J，2019，38（6）：564-568.
[3] Malosh E，Martin T，Ortiz JR，et al. The risk of lower respiratory tract infection following influenza virus infection：A systematic and narrative review [J]. Vaccine，2018，36（1）：141-147.
[4] Gavrieli H，Dagan R，Givon-Lavi N，et al. Unique Features of Hospitalized Children with Alveolar Pneumonia Suggest Frequent Viral-Bacterial Coinfections [J]. Pediatr Infect Dis J，2020，39（7）：586-590.
[5] Majidinia M，Darband SG，Kaviani M，et al. Cross-regulation between Notch signaling pathway and miRNA machinery in cancer [J]. Dna Repair，2018，30（41）：66-67.
[6] 党娟丽，余州，陈琳，等.骨髓间充质干细胞外泌体通过Notch信号通路促进移植脂肪血管化的实验研究[J].中华整形外科杂志，2021，37（10）：1114-1121.
[7] 姚意恩，李超乾.Notch信号通路与支气管哮喘关系的研究进展[J].实用医学杂志，2019，35（2）：315-317.
[8] 中华医学会儿科学分会呼吸学组，《中华儿科杂志》编辑委员会.儿童社区获得性肺炎管理指南（2013修订）（上）[J].中华儿科杂志，2013，51（10）：745-752.
[9] 王卫平.儿科学[M].8版.北京：人民卫生出版社，2013：269-287．
[10] 陈智斌，浦懋懋，姚俊，等.靶向Notch信号通路与内耳发育相关microRNA的筛选及microRNA-384-5p的实验分析[J].中华耳鼻咽喉头颈外科杂志，2018，53（11）：830-837.
[11] Lucas S，Leach M，Kumar S. Complementary and alternative medicine utilisation for the management of acute respiratory tract infection in children：A systematic review [J]. Complement Ther Med，2018，37（10）：158-166.
[12] 戎萍，马融，张喜莲，等.细菌溶解产物胶囊防治儿童反复呼吸道感染有效性和安全性的Meta分析[J].中国药房，2018，29（12）：1702-1706.
[13] 苗小倩，张碧玉，李亚琴，等.肺超声在儿童社区获得性肺炎中的诊断价值[J].临床肺科杂志，2021，26（12）：1866-1869.
[14] 付玉林，董艳，李静.2018—2019年北京市儿童社区获得性肺炎的病原学分析及临床特点[J].中国医药科学，2022，12（8）：126-129.
[15] 古丽加马丽·阿不都拉，阿衣吐拉·卡地尔.支气管肺泡灌洗液IL-6与HMGB1水平在老年重症肺部感染病情及预后评价中的价值[J].中国临床研究，2023，36（4）：532-536.
[16] 汤建华，樊頔，牛玉春，等.lncRNA-GAS5调节Notch通路对肺癌A549细胞血管生成拟态的影响[J].临床与实验病理学杂志，2019，35（12）：1412-1417.
[17] 牛树荣，孙剑经，任海玉，等.姜黄素通过抑制Notch1信号通路逆转人食管癌Eca-109/VCR细胞对长春新碱的耐药性[J].肿瘤，2018，38（6）：526-534.
[18] 陈翔天，程超，谢伊代·图尔荪托合提，等.扁塑藤素调控Notch信号通路诱导人肺癌条件重编程细胞死亡的作用机制研究[J].中国医院药学杂志，2019，39（20）：2025-2030.
[19] Schuetz P，Wirz Y，Mueller B. Reassessment of a meta-analysis of procalcitonin-guided antibiotic therapy for lower respiratory tract infections-Authors’ reply [J]. Lancet Infect Dis，2018，18（2）：140-141.
[20] 张利华，易婷婷，徐永君.细菌感染性肺炎新生儿血清IL-6与PCT和hs-CRP的表达及诊断价值研究[J].中华医院感染学杂志，2020，30（3）：453-457.
[21] 钱树坤，刘建华，李锐.血清PCT，CRP，NLR对血流感染患者细菌类型的评估价值及其对预后的影响[J].标记免疫分析与临床，2022，29（1）：11-14.
[22] 贺元成，刘静，胡小华.血清白介素-6、淀粉样蛋白A联合降钙素原对儿童社区性获得性肺炎的诊断价值研究[J].中国当代医药，2023，30（14）：100-103.
[23] Doudin A，Becker A，Rothenberger A，et al.Relationship between serum 25-hydroxyvitamin D and red blood cell indices in German adolescents [J]. Eur J Pediatr，2018，177（4）： 583-591.
[24] 李妮妮，蒋成君，郭艳，等.基于Notch通路研究化痰降气胶囊含药血清对人支气管上皮细胞MRP1的影响[J].中药新药与临床药理，2019，30（12）：1442-1448.
[25] 王坤，朱慧志，杨磊，等.miR-139下调Notch1/Hes1通路促进骨髓间充质干细胞归巢于哮喘大鼠肺组织抑制Th2细胞炎症反应[J].细胞与分子免疫学杂志，2021，37（2）：97-104.
[26] 张媛媛，马静，何会娜，等.PTEN和Notch1在非小细胞肺癌组织中表达及临床意义[J].河北医学，2021，27（10）：1637-1643.
[27] 王坤，万磊，刘健.pSS大鼠肺功能变化与Notch通路及调节性T细胞的关系[J].中国免疫学杂志，2019，35（18）：2191-2194.
[28] 徐秋萍，肖仁栋，熊为旻，等.Notch信号通路相关基因多态性与肺癌易感性的关联研究[J].中华预防医学杂志，2018，52（3）：243-252. |
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