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| Application value of heart fatty acid binding protein combined with high-sensitivity cardiac troponin I in rapid diagnosis of acute myocardial infarction |
| CAO Jiancheng LIU Yuanhua MIN Xuefen |
| Department of Cardiovascular Medicine, the First Affiliated Hospital of Huzhou University the First People’s Hospital of Huzhou, Zhejiang Province, Huzhou 313000, China |
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Abstract Objective To explore the value of heart fatty acid binding protein (H-FABP) combined with high-sensitivity cardiac troponin I (hs-cTnI) in rapid diagnosis of acute myocardial infarction. Methods A total of 105 suspected AMI patients with chest pain as the first symptom and 200 normal reference population admitted to the First People’s Hospital of Huzhou, Zhejiang Province from March 2021 to March 2022 were selected. Serum H-FABP and hs-cTnI levels were measured immediately after admission (0 h) and 1 h after admission, and the cut-off values of H-FABP and hs-cTnI were determined. The rapid triage strategy of H-FABP combined with hs-cTnI was formulated and the diagnostic efficacy of H-FABP combined with hs-cTnI for AMI was analyzed. Results The cut-off values of serum H-FABP and hs-cTnI were 6.30 ng/ml and 10.65 pg/ml, respectively. Serum H-FABP and hs-cTnI levels in patients with suspected AMI at 0 h and 1 h after admission were higher than those in normal reference population, and the differences were statistically significant (P＜0.05). Serum H-FABP and hs-cTnI levels of patients with suspected AMI 1 h after admission were higher than those of 0 h after admission, and the differences were statistically significant (P＜0.05). According to the H-FABP combined hs-cTnI rapid triage process, 45 cases (42.86%) were included in the AMI exclusion group, 50 cases (47.62%) in the AMI inclusion group, and 10 cases (9.52%) in the observation group. The sensitivity, specificity, positive predictive value, and negative predictive value of rapid triage for AMI were 100.00%, 88.71%, 86.00%, and 100.00% respectively. The area under the curve of H-FABP+hs-cTnI in the diagnosis of AMI 1 h after adm- ission were higher than those 0 h after admission, and the differences were statistically significant (P＜0.05). Conclusion The changes of serum H-FABP and hs-cTnI levels at 0 h and 1 h after admission can rapidly diagnose or exclude most AMI, which has positive significance for realizing rapid triage of AMI and reducing the mortality and misdiagnosis rate of patients.
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