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| Clinical effect of Tongtiao Granules on unstable angina pectoris of phlegm-stasis interjunction type |
| WANG Haitao PEI Lili YANG Jingna WANG Wei GUO Jingqi |
| Qinhuangdao Hospital of Traditional Chinese Medicine, Hebei Province, Qinhuangdao 066000, China |
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Abstract Objective To explore the clinical effect of Tongtiao Granules on unstable angina pectoris of phlegm-stasis interjunction type. Methods A total of 120 patients with unstable angina pectoris treated in Qinhuangdao Hospital of Traditional Chinese Medicine of Hebei Province from April 2019 to January 2022 were selected as the study objects. They were divided into two groups by random number table method, with 60 cases in each group. The control group was treated with conventional western medicine, and the observation group was treated with Tongtiao Granules on the basis of control group, both groups were treated continuously for one course. The clinical effect of two groups was compared; traditional Chinese medicine syndrome scores, 24 h holter electrocardiogram and cardiac remodeling indexes, and Seattle angina questionnaire (SAQ) score were compared between two groups before and after treatment; the occurrence of adverse reactions during treatment was observed. Results The clinical effect of the observation group was better than that of the control group (P＜0.05). After treatment, the scores of chest tightness, chest pain, palpitation, shortness of breath, sweating, sticky mouth and body weight, and waist and knee soreness in two groups were lower than those before treatment, and observation group was lower than control group (P＜0.05). After treatment, the number of ST segment depression and the maximum ST segment depression in both groups were lower than those before treatment, and observation group was lower than control group (P＜0.05); b value and k value of left anterior wall in both groups were higher than those before treatment, and observation group was higher than control group (P＜0.05). After treatment, the score of anginal stability, physical limitation, disease awarenes, anginal frequency, and treatment satisfaction, and total score of SAQ in two groups were higher than those before treatment, and observation group was higher than control group (P＜0.05). There was no significant difference in the total incidence of adverse reactions between two groups (P＞0.05). Conclusion Tongtiao Granules can effectively improve the clinical symptoms and signs of unstable angina pectoris of coronary heart disease, electrocardiogram findings and myocardial revascularization, improve the quality of life, and do not increase adverse reactions during treatment, with high safety.
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