低频重复经颅磁刺激对颅脑外伤后认知功能及P300电位的影响

doi:10.20047/j.issn1673-7210.2023.26.20

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Abstract Objective To investigate the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) on cognitive function and P300 potential in patients with traumatic brain injury (TBI). Methods A total of 50 TBI patients hospitalized in the Department of Neurosurgery and Rehabilitation Medicine, Nantong First People’s Hospital of Jiangsu Province from December 2019 to June 2021 were selected, and they were divided into experimental group and control group, with 25 cases in each group according to the random number table method. Both groups received clinical basic treatment and conventional cognitive function training, and the experimental group was supplemented with low-frequency rTMS treatment, while control group was given sham stimulation treatment, continuous treatment for six weeks. The mini-mental state examination (MMSE) score, Loewenstein occupational therapy cognitive assessment (LOTCA) score, and P300 amplitude and latency were compared before and after treatment, the occurrence of adverse reactions during treatment was observed. Results After treatment, the scores of orientation, memory, recall, attention and computation, language ability, and MMSE total score of two groups were higher than those before treatment, and the scores of orientation, attention and computation, and MMSE total score of experimental group were higher than those of control group, and the differences were statistically significant (P＜0.05). After treatment, the scores of orientation, visual perception, spatial perception, motor use, visual motor organization, thinking operation, attention and concentration, and LOTCA total score in two groups were higher than those before treatment, and those of experimental group were higher than those of control group, and the differences were statistically significant (P＜0.05). After treatment, P300 amplitude was larger than that before treatment, and latency was shorter than that before treatment, and P300 amplitude in experimental group was higher than that in control group, and latency was shorter than that in control group, and the differences were statistically significant (P＜0.05). There were no adverse reactions such as epilepsy during treatment in both groups. Conclusion Low-frequency rTMS can significantly improve the cognitive function in patients with TBI, which is worthy of clinical application and promotion. P300 can objectively reflect the effect of rTMS on cognition function.

Key words： Traumatic brain injury Cognitive function dysfunction P300 potential Transcranial magnetic stimulation

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	ZHAI Jiajia XU Qian HAN Zhenzhen HU Zhenni WANG Liang GUO Guanlan LU Hongjian▲

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ZHAI Jiajia XU Qian HAN Zhenzhen HU Zhenni WANG Liang GUO Guanlan LU Hongjian▲. Effects of low-frequency repetitive transcranial magnetic stimulation on cognitive function and P300 potential in patients with traumatic brain injury[J]. 中国医药导报, 2023, 20(26): 95-98.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.26.20 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I26/95

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