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Effects of sST2, hs-cTnI and NLR on early myocardial injury in acute organophosphorus pesticide poisoning |
GUAN Hongbao GAO Qinhu ZOU Jie WANG Zhongzhong▲ |
Department of Emergency Medicine, Fuyang Cancer Hospital, Anhui Province, Fuyang 236000, China
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Abstract Objective To investigate the effects of soluble suppression tumorigenicity 2 (sST2), high-sensitivity troponin I (hs-cTnI) and neutrophil-to-lymphocyte ratio (NLR) on early myocardial injury in acute organophosphorus pesticide poisoning. Methods The clinical data of 166 patients with acute organophosphorus pesticide poisoning admitted to Fuyang Cancer Hospital in Anhui Province from May 2018 to July 2021 were retrospectively analyzed, and within 3 d of admission, the patients were divided into myocardial injury group (32 cases) and non-myocardial injury group (134 cases) according to whether they had concomitant myocardial injury. The levels of sST2, hs-cTnI, and NLR were measured on admission for all study subjects, and logistic regression was used to analyze the influencing factors, and the predictive value of sST2, hs-cTnI, NLR, and the combination of the three for early secondary myocardial injury in acute organophosphorus pesticide poisoning. Results The time from poisoning to admission, amount of poison taken, acute physiological, and chronic health score (APACHE Ⅱ) at admission, white blood cell count, creatine hormone isoenzyme (CK-MB), lactate dehydrogenase, sST2, hs-cTnI, NLR, and proportion of severe poisoning in the myocardial injury group were higher than those in the non-myocardial injury group, and the differences were statistically significant (P<0.05). The area under the curve (AUC) values for sST2, hs-cTnI, NLR, and the combination of the three to predict early secondary myocardial injury in acute organophosphorus pesticide poisoning were 0.718, 0.745, 0.780, and 0.853, respectively. Conclusion sST2, hs-cTnI, and NLR can be used to predict early secondary myocardial injury in acute organophosphorus pesticide poisoning, and the predictive value of the combination of the three is higher.
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