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| The mechanism and research progress of pyroptosis in arthritis |
| YANG Qinglin1 XIE Ben1 YANG Dubin1 WANG Yikun1 QIN Qingqing1 WANG Yongping2 |
1.The First School of Clinical Medical, Lanzhou University, Gansu Province, Lanzhou 730000, China;
2.Department of Orthopedics, the First Hospital of Lanzhou University, Gansu Province, Lanzhou 730000, China |
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Abstract Pyrodeath is a particular type of programmed cell death. It is regulated by the pyroporin family and is characterized by membrane perforation, cell swelling, and the release of a large number of pro-inflammatory factors. Relevant studies have shown that the key components of pyroptosis are closely related to the occurrence and development of rheumatoid arthritis, osteoarthritis, and gouty arthritis. This article mainly reviews the molecular mechanism of pyroptosis activation and its mechanism and progress in arthritis, aiming to provide reference for the related research of pyroptosis and arthritis.
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