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| Exploreing the rules of the prescription medication for the treatment of urinary diseases in the Selected Clinical Cases of Zhao Shaoqin based on data mining |
| YANG Peng1 LIU Tonghua2 WU Lili2 QIN Lingling2 ZHANG Chengfei2 PENG Chuan2 ZHANG Qiu’e2 |
1.The First Clinical Medical College, Shaanxi University of Chinese Medicine, Shaanxi Province, Xianyang 712046, China;
2.Key Laboratory of Health Care of Traditional Chinese Medicine, Ministry of Education, Beijing University of Chinese Medicine, Beijing 100029, China |
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Abstract Objective To analyze the ideas of formulae for the treatment of urological diseases in Selected Clinical Cases of Zhao Shaoqin, and to explore the rules and characteristics of Zhao Shaoqin’s clinical treatment of urological system. Methods The database was established with the medical cases involving urinary system diseases in Selected Clinical Cases of Zhao Shaoqin, Excel, SPSS and IBM SPSS Modeler statistical software were used to conduct disease distribution statistics, drug frequency statistics, sex and taste normalization statistics, efficacy classification statistics, drug pairs, angle drugs, prescription rules and cluster factor extraction of new formula analysis. Results Uremia was the most frequently discussed medical case in the database. The two herbs with the highest frequency were garden burnet root and divaricate saposhnikovia root; drug multiple cold; the most bitter taste; more return to the liver meridian; the most frequently used drugs were hemostatic agents and antipyretic agents. The core drug pairs and angle drug were obtained by association analysis, such as divaricate saposhnikovia root, danshen root-garden burnet root, madder-divaricate saposhnikovia root, garden burnet root. Three core drug combinations were sorted out by cluster analysis. Factor analysis showed that there were six groups of principal components. Conclusion Zhao Shaoqin’s treatment of urological diseases emphasized the use of ying-blood component drugs, taking into account the wei-qi component, and the use of cold and bitter drugs, mostly using liver meridian drugs.
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