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| Expression of serum lactic acid and NT-proBNP in patients with acute heart failure complicated with renal deterioration and its predictive value for renal deterioration |
| SHEN Qingqing ZHANG Xinxin WANG Jiliang |
| Ward Four, Department of Cardiology, Xingtai Third Hospital, Hebei Province, Xingtai 054000, China |
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Abstract Objective To study the expression of serum lactic acid and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with acute heart failure complicated with renal deterioration and its predictive value for renal deterioration. Methods A total of 122 patients with acute heart failure admitted to the Department of Cardiology, Xingtai Third Hospital, Hebei Province from April 2018 to November 2019 were selected. According to whether renal function deteriorated during hospitalization, they were divided into renal function deterioration group (39 cases) and non-renal function deterioration group (83 cases). Baseline data of two groups were collected, the serum lactic acid and NT-proBNP levels at admission and 72 h after admission were compared between two groups, and their predictive value for renal function deterioration was analyzed. Results The proportion of male, age >60 years old, hypertension, diabetes mellitus, history of chronic kidney disease, drinking history, taking norepinephrine, and taking furosemide in renal function deterioration group was higher than that in non-renal function deterioration group, while the hemoglobin level in renal function deterioration group was lower than that in non-renal function deterioration group (P < 0.05). At admission and 72 h after admission, the levels of blood lactic acid and NT-proBNP in renal function deterioration group were higher than those in non-renal function deterioration group (P < 0.05). Chronic kidney history, diabetes mellitus, blood lactate at admission, blood lactate at 72 h after admission, NT-proBNP at admission and NT-proBNP at 72 h after admission were independent influencing factors of renal function deterioration (OR > 1, P < 0.05). Area under the curves of blood lactate at admission, blood lactate 72 h after admission, NT-proBNP at admission, and NT-proBNP 72 h after admission in the diagnosis of renal function deterioration were 0.801, 0.760, 0.631, 0.708, respectively, which had good predictive value. Conclusion Chronic kidney history, diabetes mellitus, blood lactic acid and NT-proBNP at admission and 72 h after admission are independent risk factors for renal function deterioration in patients with acute heart failure, and blood lactate and NT-proBNP at admission and 72 h after admission can be used to predict renal function deterioration.
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