Abstract：Objective To evaluate the effect on pharmaceutical intervention of the perioperative antimicrobial drugs use in typeⅠincision in Orthopedic Department. Methods Through the DIS system of hospital, electronic medical records of perioperative antibacterial drugs used in typeⅠincision in Sichuan Orthopedic Hospital from January to June 2016 (before intervention, 127 cases in control group) and from January to June 2017 (after intervention, 133 cases in intervention group) were selected. The time of administration, drug varieties, usage and dosage, medication treatment, and so on of perioperative antibacterial drugs used in typeⅠincision in orthopedic department before and after the intervention were retrospectively analyzed. Results After intervention, the reasonable proportion of the time of administration of perioperative antibacterial drugs varieties used in intervention group was significantly increased to 84.2%, and it compared with the control group (51.2%), the difference was highly statistically significant (χ2=32.81, P=0.000). The rational proportion of perioperative antibacterial drugs used in intervention group was compared with the control group, the difference was highly statistically significant (χ2=46.27, P=0.000). Administration route of antimicrobial drugs before and after the intervention were intravenous drip, and the two groups were compared on the route of administration, the difference was not statistically significant (P > 0.05), but the dosage and frequency of medication in intervention group were higher than those of the control group (χ2=23.11, P=0.000, χ2=36.32, P=0.000). The antibacterial drug of treatment in the operation of < 24 h in the two groups were compared, the difference was not statistically significant (P > 0.05). The medication treatment in the operation of 24-48 h in the intervention group was higher than the control group (χ2=23.78, P=0.000). The medication treatment in the operation of > 48 h in the intervention group was lower than the control group (χ2=18.42, P=0.000). Conclusion The effect of pharmaceutical intervention of the perioperative antimicrobial drugs use in typeⅠincision in Orthopedic Department is definite, and can effectively improve the rational utility ratio of antibacterial drugs, reduce the occurrence of non-standard drugs use, which is worth promoting.
2018, Vol. 15 
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