妊娠期妇女甲状腺功能与血脂水平相关性研究

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摘要目的探讨妊娠期妇女甲状腺功能与血脂水平的相关性。方法选择2015年4月~2016年4月盐城市第一人民医院医院产科门诊及住院的妊娠期妇女250例。采用放射免疫法检测血清游离三碘甲腺原氨酸（FT3）、游离甲状腺素（FT4）水平；免疫荧光分析法检测血清中促甲状腺激素（TSH）水平。根据甲状腺功能测定结果分为：亚甲亢组（亚临床甲状腺功能亢进）、甲亢组（甲状腺功能亢进症）、正常组（甲状腺功能正常）、亚甲减组（亚临床甲状腺功能减退）、甲减组（甲状腺功能减退症）。每组50例。酶比色法测定各组血中总胆固醇（TC）、三酰甘油（TG）水平；免疫抑制直接测定法测定血中高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）水平。并将FT3、FT4、TSH水平与血中TC、TG、HDL-C、LDL-C水平进行相关性分析。结果各组间FT3、FT4、TSH水平与血脂水平差异均有统计学意义（P < 0.05）。妊娠期妇女TSH水平与TC、TG、LDL-C水平呈显著正相关（P < 0.05），与HDL-C水平无明显相关性（P > 0.05）。妊娠期妇女血清FT3、FT4水平与TC、TG、LDL-C水平呈显著负相关（P < 0.05），与HDL-C水平无明显相关性（P > 0.05）。结论妊娠期甲状腺功能的亢进可引起血脂TC、TG、LDL-C水平下降。

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	胥柯边德志王春雷黄飞刘艳梅▲

关键词 ：妊娠, 血脂, 促甲状腺激素, 游离甲状腺激素, 游离三碘甲腺原氨酸

Abstract：Objective To investigate the correlation between thyroid function and blood lipid in pregnant women. Methods From April 2015 to April 2016, 250 cases of pregnant women were admitted to the Yancheng City No.1 People′s Hospital were selected, and they were divided into subclinical thyroid function hyperfunction group, hyperthyroidism group and normal group, subclinical hypothyroidism group, hypothyroidism group, 50 cases per group. Radioimmunoassay was used to detect the serum free triiodide (FT3) and free thyroxine (FT4) levels. Immunofluorescence analysis was used to detect the levels of thyrotropin (TSH) in serum. Determination of blood TC and TG levels in each group was taken by enzyme colorimetry. Determination of HDL-C and LDL-C levels was taken by immunosuppressive. The correlation analysis was conducted with FT3, FT4, TSH level and TC, TG, HDL-C level in blood. Results There was a statistical difference in FT3, FT4, TSH and serum lipid between every group (P < 0.05). The TSH level has positively correlated with TC, TG, LDL-C level (P < 0.05), and has no significant correlation with HDL-C (P > 0.05). The FT3 and FT4 levels had significantly negatively correlated with TC, TG and LDL-C levels (P < 0.05), and had no significant correlation with HDL-C level (P > 0.05). Conclusion Thyroid hormone levels in pregnancy are closely related to blood lipids. Hyperthyroidism in pregnancy can lead to levels of TG, TG, and LDL-C decreased.

Key words： Pregnancy Blood lipids Thyroid-stimulating hormone Free thyroid hormones Free triiodothyronine

基金资助:江苏省盐城市科技计划项目（YK2014006）。

通讯作者: ▲通讯作者

作者简介: 胥柯（1980.10-），女，出生年月日，硕士，副主任医生；研究方向：妊娠期糖尿病及妊娠期甲状腺疾病的诊治。

引用本文:

胥柯边德志王春雷黄飞刘艳梅▲. 妊娠期妇女甲状腺功能与血脂水平相关性研究[J]. 中国医药导报, 2018, 15(11): 91-94.
XU Ke BIAN Dezhi WANG Chunlei HUANG Fei LIU Yamei▲. Correlation analysis between thyroid function and blood lipid in pregnant women. 中国医药导报, 2018, 15(11): 91-94.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2018/V15/I11/91

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