Abstract：Objective To discuss the curative effect of Pramipexole and hyperbaric oxygen chamber in the treatment of Parkinson disease combined with dyssomnia. Methods The clinical data of 135 patients with Parkinson disease combined with dyssomnia treated in Affiliated Hospital of Yan'an University from December 2014 to December 2016 was analyzed retrospectively. The patients were divided into three groups according to different treatment methods, with 45 cases in each group. The patients in the Pramipexole group were treated with oral Pramipexole Dihydrochloride Tablets, and the patients in the hyperbaric oxygen chamber group were treated with hyperbaric oxygen therapy, the patients in the combination group were treated with hyperbaric oxygen and Pramipexole Dihydrochloride Tablets. All groups were treated for 2 months. The sleep related indices (time in bed, total sleep time, sleep efficiency, sleep onset latency, number of awakenings) and polysomnogram monitoring parameters [sleep time at phase Ⅰ-Ⅱ, slow-wave sleep (SWS), and rapid eye movement sleep (REM) time] after treatment in the three groups were observed and recorded. The scores of Pittsburgh sleep quality index scale (PSQI), Epworth sleepiness scale (ESS), unified Parkinson disease rating scale (UPDRS-Ⅲ), Hoehn-Yahr grading (H-Y grading) of Parkinson disease among the three groups before and after treatment were compared. The conditions of adverse reactions in the three groups were recorded. Results There were no significant differences in the scores of sleep quality related scales among the three groups before treatment (P ＞ 0.05). There were no statistically significant differences in the scores of sleep quality related scales of the Pramipexole group and hyperbaric oxygen chamber group before and after treatment (P ＞ 0.05), while the scores of PSQI, ESS and UPDRS-Ⅲ after treatment in the combination group were significantly lower than those before treatment (P ＜ 0.05), and the scores of PSQI and ESS in the combination group were significantly lower than those of Pramipexole group and hyperbaric oxygen chamber group (P ＜ 0.05), while the scores of UPDRS-Ⅲ and H-Y grading had no significant differences compared with those of Pramipexole group and hyperbaric oxygen chamber group (P ＞ 0.05). After treatment, the time in bed, total sleep time and sleep efficiency in the combination group were significantly higher than those of Pramipexole group and hyperbaric oxygen chamber group (P ＜ 0.05), the number of awakenings was significantly less than those of Pramipexole group and hyperbaric oxygen chamber group (P ＜ 0.05). There were no statistically significant differences of the other sleep indices among the three groups (P ＞ 0.05). No obvious adverse reactions occurred in the three groups after treatment. Conclusion Pramipexole combined with hyperbaric oxygen chamber in the treatment of Parkinson disease combined with dyssomnia has significant clinical effect, which can significantly improve sleep efficiency and quality, it is worthy of clinical promotion.
刘莹莹 高喜斌 马利 师强▲. 普拉克索联合高压氧舱治疗帕金森病合并睡眠障碍的效果[J]. 中国医药导报, 2018, 15(11): 78-81,90.
LIU Yingying GAO Xibin MA Li SHI Qiang▲. Curative effect of Pramipexole combined with hyperbaric oxygen chamber in the treatment of Parkinson disease combined with dyssomnia. 中国医药导报, 2018, 15(11): 78-81,90.
2018, Vol. 15 
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