The diagnostic value of growth differentiation factor-15 and N-terminal B-type natriuretic peptide prosoma and high-sensitivity C-reactive protein in patients with acute heart failure
HUANG Haiyan1 CUI Ying2 HONG Yunyu1 LI Yulan1 WANG Xingjun1 ZHONG Wenxiu1 LI Meifeng1
1.Department of Emergency, the Second Hospital of Yanbian, Jilin Province, Yanji 133000, China;
2.Department of ICU, the Second Hospital of Yanbian, Jilin Province, Yanji 133000, China
Abstract：Objective To explore the expression level and diagnostic value of serum growth differentiation factor-15 (GDF-15), N-terminal B-type natriuretic peptide prosoma (NT-proBNP) and high-sensitivity C-reactive protein (CRP) in patients with acute heart failure (AHF) and patients with different severity of AHF. Methods A total of 77 patients with AHF (AHF group) and 60 cases of healthy examined people (control group) from April 2014 to April 2016 in the Second Hospital of Yanbian were selected. The expression level of serum GDF-15 and NT-proBNP were detected by ELISA, the expression of hs-CRP was detected by immunochromatography, routine electrocardiogram and echocardiography were performed to examine the left ventricular ejection fraction (LVEF) and chest X-ray examination. The correlation between GDF-15, NT-proBNP, hs-CRP expression level and the three factors were analyzed. Results Compared with the control group, the expression of GDF-15, NT-proBNP and hs-CRP were significantly increased and the left ventricular ejection fraction (LVEF) was significantly reduced in AHF group, the difference was statistically significant (P ＜ 0.05). The levels of NT-proBNP, hs-CRP among clinical grades Ⅰto Ⅳ had increased trend, the difference was not statistically significant (P ＞ 0.05). GDF-15 and hs-CRP were positively correlated to NT-proBNP, hs-CRP was positivly correlated to NT-proBNP, LVEF and GDF-15 were negatively correlated to NT-proBNP (P ＜ 0.01). The ROC curve analysis showed that the areas under the curve of NT-proBNP, GDF-15 and hs-CRP had statistical significance in diagnosing AHF (P ＜ 0.05), the diagnostic ability was NT-proBNP ＞ GDF-15 ＞ hs-CRP. Conclusion The serum levels of GDF-15, NT-proBNP and hs-CRP are significantly elevated in patients with AHF, and increasd as the clinical severity. The serum GDF-15 can be used as a new index for diagnosis, treatment and estimating prognosis of patients with AHF. GDF-15 combined with the detection of NT-proBNP and hs-CRP has great significance in diagnosing and treating, distinguishing risk stratification and judging prognosis AHF.
黄海燕1 崔瑛2 洪云玉1 李玉兰1 王兴军1 仲文秀1 李美峰1. 生长分化因子-15与N末端-B型利钠肽原及超敏C反应蛋白在急性心力衰竭中的诊断价值[J]. 中国医药导报, 2018, 15(11): 54-58.
HUANG Haiyan1 CUI Ying2 HONG Yunyu1 LI Yulan1 WANG Xingjun1 ZHONG Wenxiu1 LI Meifeng1. The diagnostic value of growth differentiation factor-15 and N-terminal B-type natriuretic peptide prosoma and high-sensitivity C-reactive protein in patients with acute heart failure. 中国医药导报, 2018, 15(11): 54-58.
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2018, Vol. 15 
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