Research progress of Wnt signaling pathway and osteoporosis treatment
WANG Guozhu1 XIAO Bin1 DONG Bo2 YAO Jie2 CHEN Zhihui1 QIAN Bing1 Zhang Liping1
1.Department of Orthopedics, the Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Shaanxi Province, Xianyang 712000, China;
2.Department of Orthopedics, Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Shaanxi Province, Xianyang 712000, China
Abstract：Adult bone is a multifunctional organ that has been continuously reshaped. The homeostasis of bone requires the balance between osteoclast bone absorption and osteogenesis. If this imbalance can lead to osteoporosis, sclerosing osteopathy and other bone diseases. In order to find effective and safe treatment methods to regulate bone formation, the molecular mechanism of bone cell differentiation and activity must be elucidated. Gene researches in humans and mice have established Wnt signaling as a key mechanism for stimulating osteoblast differentiation and activity.This paper reviews the related mechanisms of Wnt signaling pathway and bone formation and the treatment of osteoporosis.
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2018, Vol. 15 
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