宫颈病变锥切术后高危型人乳头瘤状病毒转归及相关因素研究进展

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摘要高危型人乳头瘤病毒（HR-HPV）感染是发生宫颈鳞状上皮内病变（SIL）和宫颈癌发生及发展的必要条件。宫颈高度鳞状上皮内病变（HSIL）及宫颈鳞癌ⅠA1期在锥切术后残留与复发，甚至进展为更严重病变的情况仍然存在。HR-HPV的转归与宫颈病变转归高度相关，HSIL及宫颈鳞癌ⅠA1期行锥切术后的处理及随访应参考HR-HPV监测情况。HR-HPV感染指标在随访中对宫颈病变转归的具体指导意义和影响HR-HPV转归的高危因素仍需深入研究。

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	王依妮何玥吴玉梅

关键词 ：高危型人乳头瘤病毒, 宫颈高度鳞状上皮内病变, 锥切术, 转归

Abstract：High-risk human papillomavirus (HR-HPV) infection is a necessary condition in the occurrence and development of cervical squamous intraepithelial lesion (SIL) and cervical cancer. There are cases that high-grade squamous intraepithelial lesion (HSIL) and cervical squamous cancer at stageⅠA1 remain or reoccur, or even become more severe after conization. The prognosis of HR-HPV has high correlation with the prognosis of cervical lesion. The treatment and follow-up of HSIL and cervical squamous cancer at stageⅠA1 after conization should be consulted in the monitoring conditions of HR-HPV. It is worthwhile making further study in the specific practical significance of HR-HPV infection indices for the prognosis of cervical lesion during follow-up, as well as the high-risk factors that influence the prognosis of HR-HPV.

Key words： High-risk human papillomavirus High-grade squamous intraepithelial lesion Conization Prognosis

基金资助:北京市医院管理局重点医学专业发展项目（ZYLX201705）；
北京市医院管理局“青苗”人才培养计划项目（QML20151302）；
北京市优秀人才培养资助项目（20140000 21469G246）。

通讯作者: 吴玉梅（1959.11-），女，博士，主任医师，博士生导师；研究方向：妇科肿瘤。

作者简介: 王依妮（1992.10-），女，首都医科大学2016级妇产科学专业在读硕士研究生；研究方向：妇科肿瘤。

引用本文:

王依妮何玥吴玉梅. 宫颈病变锥切术后高危型人乳头瘤状病毒转归及相关因素研究进展[J]. 中国医药导报, 2018, 15(11): 25-28.
WANG Yini HE Yue WU Yumei. Research progress on the prognosis of high-risk human papillomavirus infection after conization of cervical lesions and its related factors. 中国医药导报, 2018, 15(11): 25-28.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2018/V15/I11/25

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