Abstract：Objective To analyze the correlation between the change in carotid intima / media membrane (I/M) ratio and renal atherosclerosis in experimental rabbit carotid atherosclerosis models. Methods Forty-eight rabbits were randomly divided into the blank group, the control group and the model group by the random number table method, with 16 rabbits in each group. The blank group was not given any intervention, which was given basal feed. The control group was given high-fat diet of 120 g/d. The model group was given 7 d of high-fat diet and then the rabbits were changed into bilateral carotid atherosclerosis models through carotid intima air drying after 12 h of fasting (without fasting water). The bilateral operative carotid arteries and renal artery specimens of all rabbits were obtained to analyze the I/M ratio after routine paraffin embedding, sectioning and HE staining. Serum levels of triglyceride (TG), total cholesterol (TC) and C-reactive protein (CRP) were determined at the end of the experiment. Urinary microalbumin / urine creatinine (UACR) was analyzed and correlation analysis was performed. Results HE staining under light microscope was normal in the carotid artery and renal artery of rabbits in the blank group. In the control group, there was slight intimal hyperplasia in the carotid artery and slight hyperplasia and stenosis in the renal artery, without obvious lipid deposition. In the model group, there was obviously proliferated and thickened carotid intima, a large number of foam cells accumulated in the intima, extensively proliferated intima of the renal artery and seriously narrowed vessels, and thickened intima was accumulated foam cells at high magnification. Compared with the blank group, the carotid artery, renal artery I/M ratio in the control group and model group were significantly increased, serum TG, TC, CRP and UACR were significantly increased, and the carotid artery, renal artery I/M ratio and serum TG, TC, CRP and UACR in the model group were significantly higher than those of control group, the differences were statistically significant (P ＜ 0.05). The I/M ratio of carotid artery in rabbit carotid atherosclerosis models was positively correlated with the I/M ratio of renal artery, CRP and UACR (P ＜ 0.05), but there was no significant correlation with TG or TC (P ＞ 0.05). Conclusion Carotid atherosclerosis can promote the occurrence of renal atherosclerosis, which may be related to inflammatory reactions, vascular endothelial cell injury and renal vascular diseases.
陈徐亮 周野 杨鹏麟. 实验性家兔颈动脉粥样硬化模型中颈动脉I/M值与肾动脉粥样硬化的相关性研究[J]. 中国医药导报, 2018, 15(11): 12-16.
CHEN Xuliang ZHOU Ye YANG PenglinDepartment of Cardiovascular Medicine, the Second Hospital Affiliated to Wenzhou Medical University, Zhejiang Province, Wenzhou 325000, China. Study on the correlation between the carotid I/M ratio and renal atherosclerosis in experimental rabbit carotid atherosclerosis models. 中国医药导报, 2018, 15(11): 12-16.
2018, Vol. 15 
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