Application of pepsinogen, thymidine kinase 1 joint detection in the screening for gastric cancer
LI Weibing1 WANG Kuiming1 HOU Weiwei1 YU Haizhong1 YUAN Jianfen1 YAO Hui2 XIAO Chunhong3▲
1.Department of Laboratory Medicine, Nantong Hospital of Traditional Chinese Medicine, Jiangsu Province, Nantong 226001, China;
2.Department of Laboratory Medicine, Nantong Maternal and Children Health Care Service Hospital, Jiangsu Province, Nantong 226000, China;
3.Department of Laboratory Medicine, Nantong Tumor Hospital, Jiangsu Province, Nantong 226361, China
Abstract：Objective To investigate the value of pepsinogen (PG) and thymidine kinase 1 (TK1) combined detection for gastric cancer screening. Methods Two hundred and fifty-eight cases were included in the research from February 2016 to June 2017, who were stomach cancer (n=178) [including early gastric cancer (n=46), progress gastric cancer (n=60)], atrophic gastritis (n=72), and healthy individuals (n=80) as control respectively. Blood PG and TK1 were assayed with enzyme linked immonosorbent assay (ELISA) and Western blot-enayme immunoassay chemilumiescence commercial kit. Results PGⅠand PGⅠ/Ⅱ(PGR) of gastric cancer were lower than those of atrophic gastritis and normal control (P < 0.05), and which of advanced gastric cancer were lower than those of early gastric cancer (P < 0.05). TK1 of gastric cancer was higher than that of atrophic gastritis and normal control patients (P < 0.05), which had nothing to do with the staging of gastric cancer (P > 0.05). Sensitivity and specificity for PG and TK1 were 52.1%, 81.9% and 47.2%, 86.1% respectively. Sensitivity and specificity for PG and TK1 combined assay were 81.1% and 79.2%, which were significantly higher than those of individual assay (P < 0.05). Conclusion This study shows that PG and TK1 combined detection has excellent value for gastric cancer screening.
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2018, Vol. 15 
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