The interaction of Clopidogrel with SSRIs mediated by CYP2C19
FAN Youmin1 MA Xiuping2 CHEN Songjie1 GENG Deqin2▲
1.Clinical College, Xuzhou Medical University, Jiangsu Province, Xuzhou 221000, China;
2.Department of Neurology, Affiliated Hospital of Xuzhou Medical University, Jiangsu Province, Xuzhou 221000, China
Abstract：Along with the general rising of the incidence of post-stroke depression, selective serotonin reuptake inhibitors (SSRI) and dual anti-platelet therapy are widely used for patients with post-stroke depression in clinic. However, both SSRI and Clopidogrel are metabolized by hepatocyte pigment P450 isoenzyme system, some meta-analysis and small sample researches indicate that SSRI can reduce the anti-platelet effects of Clopidogrel by inhibiting the activity of hepatocyte pigment P450 isoenzyme CYP2C19. According to the different chemical structures and pharmacokinetic characteristics of SSRIs, the degrees of suppression of SSRI are not alike. This article summaries the drug metabolism pathway, mechanism and clinical research progress of this two drugs.
范佑民1 马修平2 陈松洁1 耿德勤2▲. 氯吡格雷与SSRI类药通过CYP2C19介导的相互作用[J]. 中国医药导报, 2018, 15(10): 51-54,67.
FAN Youmin1 MA Xiuping2 CHEN Songjie1 GENG Deqin2▲. The interaction of Clopidogrel with SSRIs mediated by CYP2C19. 中国医药导报, 2018, 15(10): 51-54,67.
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2018, Vol. 15 
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