The related research progress of epidermal growth factor receptor - extracellular signal regulated kinase signaling pathway in the ischemic cerebrovascular disease
ZHANG Qin AO Ting XIAO Shuying XU Na ZHANG Ruihua▲
Department of Geriatric Medicine, Luhe Hospital, Capital Medical University, Beijing 101149, China
Abstract:Ischemic cerebrovascular disease (ICD) is a common chronic disabling disease. This disease seriously affects the quality of lives of patients. The research shows that the epidermal growth factor receptor-extracellular signal regulated kinase (EGFR-ERK) pathway plays an important role on the pathophysiology process in ICD. However, the mechanism is still unclear. This article reviews the progress of the EGFR-ERK pathway in ICD, which provides references for further basic research and clinical treatment of ICD.
张芹 奥婷 肖淑英 许娜 张瑞华▲. 表皮生长因子受体-细胞外信号调节激酶信号通路在缺血性脑血管病中的相关研究进展[J]. 中国医药导报, 2018, 15(9): 36-40.
ZHANG Qin AO Ting XIAO Shuying XU Na ZHANG Ruihua▲. The related research progress of epidermal growth factor receptor - extracellular signal regulated kinase signaling pathway in the ischemic cerebrovascular disease. 中国医药导报, 2018, 15(9): 36-40.
[1] Tong X,George MG,Gillespie C,et al. Trends in hospitalizations and cost associated with stroke by age,United States 2003-2012 [J]. Int J Stroke,2016,11(8):874-881.
[2] James R,Searcy JL,Le Bihan T,et al. Proteomic analysis of mitochondria in APOE transgenic mice and in response to an ischemic challenge [J]. J Cereb Blood Flow Metab,2012,32(1):164-176.
[3] 余剑,曾进胜,盛文利,等.表皮生长因子促进大鼠脑梗死后的早期神经功能康复[J].中国神经精神疾病杂志, 2005,31(2):111-114.
[4] 余剑,曾进胜,赵湛,等.表皮生长因子促进脑梗死后室管膜下区神经干细胞迁徙机制的初步研究[J].中风与神经疾病杂志,2007,24(1):4-7.
[5] 周金桥,刘秋红,孙剑瑞.颅脑损伤并发应激性溃疡时血清表皮生长因子浓度和氧化物岐化酶活力的变化及临床意义[J].2010,17(1):72-74.
[6] 沈顺姬,杨净,李婧,等.大鼠局灶性脑缺血损伤中表皮生长因子的表达变化的意义[J].中国临床康复,2003,7(31):4180-4181.
[7] Rocourt DV,Mehta VB,Besner GE. Heparin-binding EGF-like growth factor decreases inflammatory cytokine expression after intestinal ischemia/reperfusion injury [J]. J Surg Res,2007,139(2):269-273.
[8] Subiros N,Perez-Saad H,Aldana L,et al. Neuroprotective effect of epidermal growth factor plus growth hormone-releasing peptide-6 resembles hypothermia in experimental stroke [J]. Neurol Res,2016,38(11):950-958.
[9] Wang Y,Cooke MJ,Lapitsky Y,et al. Transport of epidermal growth factor in the stroke-injured brain [J]. J Control Release,2011,149(3):225-235.
[10] Cooke MJ,Wang Y,Morshead CM,et al. Controlled epi-cortical delivery of epidermal growth factor for the stimulation of endogenous neural stem cell proliferation in stroke-injured brain [J]. Biomaterials,2011,32(24):5688-5697.
[11] Jeffers MS,Hoyles A,Morshead C,et al. Epidermal growth factor and erythropoietin infusion accelerate functional recovery in combination with rehabilitation [J]. Stroke,2014,45(6):1856-1858.
[12] 张鸿,宋利春,庞秀慧.急性脑梗死患者血清表皮生长因子含量与神经功能缺损评分的关系[J].现代康复,2001, 5(8):52-55.
[13] Hanke M,Farkas LM,Jakob M,et al. Heparin-binding epidermal growth factor-like growth factor:a component in chromaffin granules which promotes the survival of nig?鄄rostriatal dopaminergic neurones in vitro and in vivo [J]. Neuroscience,2004,124(4):757-766.
[14] Hermann PM,Nicol JJ,Nagle GT,et al. Epidermal growth factor-dependent enhancement of axonal regeneration in the pond snail Lymnaea stagnalis:role of phagocyte survival [J]. J Comp Neurol,2005,492(4):383-400.
[15] Garcia DBD,Martinez NS,Coro-Antich RM,et al. Epidermal growth factor and growth hormone-releasing peptide-6:combined therapeutic approach in experimental stroke [J]. Restor Neurol Neurosci,2013,31(2):213-223.
[16] 景迎春,李擎瑜,刘彬,等.HB-EGF可挽救ADAM17缺失导致的大脑皮层神经前体细胞分化迁移异常[J].复旦学报:自然科学版,2017,56(5):602-609.
[17] Jin K,Sun Y,Xie L,et al. Post-ischemic administration of heparin-binding epidermal growth factor-like growth factor(HB-EGF)reduces infarct size and modifies neurogenesis after focal cerebral ischemia in the rat [J]. J Cereb Blood Flow Metab,2004,24(4):399-408.
[18] 李晓波,丁新生.碱性成纤维细胞生长因子、表皮生长对脑缺血大鼠内源性神经干细胞增殖的影响[J].临床神经病学杂志,2006,19(3):188-190.
[19] Menard S,Casalini P,Campiglio M,et al. Role of HER2/neu in tumor progression and therapy [J]. Cell Mol Life Sci,2004,61(23):2965-2978.
[20] Steelman LS,Franklin RA,Abrams SL,et al. Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy [J]. Leukemia,2011,25(7):1080-1094.
[21] Mebratu Y,Tesfaigzi Y. How ERK1/2 activation controls cell proliferation and cell death:is subcellular localization the answer?[J]. Cell Cycle,2009,8(8):1168-1175.
[22] Hopfner M,Schuppan D,Scherubl H. Growth factor receptors and related signalling pathways as targets for novel treatment strategies of hepatocellular cancer [J]. World J Gastroenterol,2008,14(1):1-14.
[23] Davidson B,Givant-Horwitz V,Lazarovici P,et al. Matrix metalloproteinases(MMP),EMMPRIN(extracellular matrix metalloproteinase inducer)and mitogen-activated protein kinases(MAPK):co-expression in metastatic serous ovarian carcinoma [J]. Clin Exp Metastasis,2003, 20(7):621-631.
[24] Chang F,Steelman LS,Lee JT,et al. Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors:potential targeting for therapeutic intervention [J]. Leukemia,2003,17(7):1263-1293.
[25] Roovers K,Assoian RK. Integrating the MAP kinase signal into the G1 phase cell cycle machinery [J]. Bioessays,2000,22(9):818-826.
[26] Wang ZF,Tang LL,Yan H,et al. Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice [J]. Pharmacol Biochem Behav,2006,83(4):603-611.
[27] Zuo Z,Wang Y,Huang Y. Isoflurane preconditioning protects human neuroblastoma SH-SY5Y cells against in vitro simulated ischemia-reperfusion through the activation of extracellular signal-regulated kinases pathway [J]. Eur J Pharmacol,2006,542(1-3):84-91.
[28] Minutoli L,Antonuccio P,Romeo C,et al. Evidence for a role of mitogen-activated protein kinase 3/mitogen-activated protein kinase in the development of testicular ischemia-reperfusion injury [J]. Biol Reprod,2005,73(4):730-736.
[29] Sawe N,Steinberg G,Zhao H. Dual roles of the MAPK/ERK1/2 cell signaling pathway after stroke [J]. J Neurosci Res,2008,86(8):1659-1669.
[30] Sironi L,Banfi C,Brioschi M,et al. Activation of NF-kB and ERK1/2 after permanent focal ischemia is abolished by simvastatin treatment [J]. Neurobiol Dis,2006,22(2):445-451.
[31] Meller R,Stevens SL,Minami M,et al. Neuroprotection by osteopontin in stroke [J]. J Cereb Blood Flow Metab,2005,25(2):217-225.
[32] Chen WY,Chang MS. IL-20 is regulated by hypoxia-inducible factor and up-regulated after experimental ischemic stroke [J]. J Immunol,2009,182(8):5003-5012.
[33] Wang ZQ,Wu DC,Huang FP,et al. Inhibition of MEK/ERK 1/2 pathway reduces pro-inflammatory cytokine interleukin-1 expression in focal cerebral ischemia [J]. Brain Res,2004,996(1):55-66.
[34] Gu Z,Jiang Q,Zhang G. Extracellular signal-regulated kinase 1/2 activation in hippocampus after cerebral ischemia may not interfere with postischemic cell death [J]. Brain Res,2001,901(1-2):79-84.
[35] Wang X,Zhu C,Qiu L,et al. Activation of ERK1/2 after neonatal rat cerebral hypoxia-ischaemia [J]. J Neurochem,2003,86(2):351-362.
[36] Jiang Z,Zhang Y,Chen X,et al. Activation of Erk1/2 and Akt in astrocytes under ischemia [J]. Biochem Biophys Res Commun,2002,294(3):726-733.
[37] Labussiere M,Boisselier B,Mokhtari K,et al. Combined analysis of TERT,EGFR,and IDH status defines distinct prognostic glioblastoma classes [J]. Neurology,2014,83(13):1200-1206.
[38] Chamberlain MC,Sanson M. Combined analysis of TERT,EGFR,and IDH status defines distinct prognostic glioblastoma classes [J]. Neurology,2015,84(19):2007.
[39] Taylor TE,Furnari FB,Cavenee WK. Targeting EGFR for treatment of glioblastoma:molecular basis to overcome resistance [J]. Curr Cancer Drug Targets,2012,12(3):197-209.
[40] Goncharenko-Khaider N,Matte I,Lane D,et al. Ovarian cancer ascites increase Mcl-1 expression in tumor cells through ERK1/2-Elk-1 signaling to attenuate TRAIL-induced apoptosis [J]. Mol Cancer,2012,11:84.
[41] Wang Z,Yuan H,Sun C,et al. GATA2 promotes glioma progression through EGFR/ERK/Elk-1 pathway [J]. Med Oncol,2015,32(4):87.
[42] Ferrer I,Planas AM. Signaling of cell death and cell survival following focal cerebral ischemia:life and death struggle in the penumbra [J]. J Neuropathol Exp Neurol,2003,62(4):329-339.
[43] Tsubokawa T,Yamaguchi-Okada M,Calvert JW,et al. Neurovascular and neuronal protection by E64d after focal cerebral ischemia in rats [J]. J Neurosci Res,2006,84(4):832-840.
[44] Anagli J,Abounit K,Stemmer P,et al. Effects of cathepsins B and L inhibition on postischemic protein alterations in the brain [J]. Biochem Biophys Res Commun,2008,366(1):86-91.
[45] Iadecola C,Alexander M. Cerebral ischemia and inflammation [J]. Curr Opin Neurol,2001,14(1):89-94.
[46] Stoll G, Jander S, Schroeter M. Detrimental and beneficial effects of injury-induced inflammation and cytokine expression in the nervous system[J]. Adv Exp Med Biol, 2002, 513: 87-113.
[47] Wang ZQ,Chen XC,Yang GY,et al. U0126 prevents ERK pathway phosphorylation and interleukin-1beta mRNA production after cerebral ischemia [J]. Chin Med Sci J,2004,19(4):270-275.
[48] 韩新光,温博贵.表皮生长因子受体抑制剂AG148对舌鳞状细胞癌细胞Tca8113细胞外信号调节激酶抑制作用的研究[J].现代口腔医学杂志,2006,20(2):164-166.
[49] Yang SI,Yuan Y,Jiao S,et al. Calcitonin gene-related peptide protects rats from cerebral ischemia/reperfusion injury via a mechanism of action in the MAPK pathway [J]. Biomed Rep,2016,4(6):699-703.
[50] Jeffries MA,Urbanek K,Torres L,et al. ERK1/2 Activation in Preexisting Oligodendrocytes of Adult Mice Drives New Myelin Synthesis and Enhanced CNS Function [J]. J Neurosci,2016,36(35):9186-9200.
[51] Maddahi A,Edvinsson L. Cerebral ischemia induces microvascular pro-inflammatory cytokine expression via the MEK/ERK pathway [J]. J Neuroinflammation,2010,7:14.