Effect of prophylactic medication on febrile non-hemolytic transfusion reaction：a meta-analysis#br#
LI Shuanghua1 LI Zhenhua2 LIU Chunyong3
1.The First Department of Hepatology, Zhujiang Hospital of Southern Medical University, Guangdong Province, Guangzhou 510282, China;
2.Department of General Surgery, the Second People’s Hospital of Xiping County in Henan Province, Henan Province, Zhumadian 463900, China; 3.Department of Basic Medicine, Zhaoqing Medical College, Guangdong Province, Zhaoqing 526020, China
Abstract：Objective To investigate and analyze the effect of prophylactic medication before transfusion on the incidence of fever and allergic blood transfusion reaction. Methods Clinical controlled trials on prophylactic medication before transfusion published in PubMed, EmBase, The Cochrane Library, China National Knowledge Internet, China Science and VIP, WanFang Data base, and CBM from inception to October 2020 were collected. They were divided into prophylactic medication before transfusion group and control group (no prophylactic medication or placebo was administered before transfusion). Two researchers conducted methodological quality evaluation according to the systematic evaluation quality evaluation standard, extracted data, and performed meta-analysis with RevMan 5.3 software. Results Twelve articles were included. The results showed that the incidence of fever was significantly lower in the prophylactic medication before transfusion group than in the control group, and the difference was statistically significant (OR = 0.70, 95%CI: 0.55-0.88, P = 0.002). There was no significant difference in the incidence of allergic reaction between the prophylactic medication before transfusion group and the control group (OR = 0.87, 95%CI: 0.62-1.62, P = 0.42). Funnel plot showed that there was no publication bias in the included literature. Conclusion Prophylactic medication before transfusion can reduce the incidence of febrile reaction, but not allergic reaction. However, the conclusions need to be supported by high-quality randomized controlled trials.
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