Abstract：Objective To systematically evaluate the association between the incidence of coronary artery heart disease and the MTHFR C677 allele in China. Methods Case-control studies on the correlation between coronary artery heart disease and MTHFR C677 C/T gene were searched in English databases (PubMed, Embase, Cochrane Library) and Chinese databases (CNKI, VIP, Wanfang Data) from inception to February 2021. The quality of the included literatures was evaluated. Data were meta-analyzed using RevMan 5.0 software. Results A total of 2412 cases were included in eight studies, including 1501 cases in the coronary artery heart disease group and 911 cases in the normal group. Meta-analysis showed that the expression of MTHFR C677 CC allele in coronary artery heart disease group was lower than that in normal group (OR = 1.59, 95%CI: 1.17-2.15, P = 0.003). There was no significant difference in MTHFR C677 CT allele expression between coronary artery heart disease group and normal group (OR = 0.91, 95%CI: 0.76-1.09, P = 0.30). The expression of MTHFR C677 TT allele in coronary artery heart disease group was higher than that in normal group (OR = 0.64, 95%CI: 0.52-0.79, P ＜ 0.000 01). Conclusion The expression of MTHFR C677T gene is related to the incidence of coronary artery heart disease in Chinese population, and the TT allele expression is higher in coronary artery heart disease population.
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