中国人群MTHFR C677基因多态性与冠心病发病相关性的meta分析

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摘要目的系统评价中国人群MTHFR C677等位基因与冠心病发病相关性。方法通过计算机检索英文数据库（PubMed、Embase、Cochrane图书馆）及中文数据库（CNKI、VIP、万方数据库）中有关冠心病与MTHFR C677 C/T基因相关性的病例对照研究，检索时间从建库至2021年2月。对纳入文献进行研究质量评估。采用RevMan 5.0 软件对数据进行meta分析。结果共纳入8项研究，共2412例，包括冠心病组1501例，正常组911名。meta分析结果显示，冠心病组MTHFR C677 CC等位基因表达低于正常组（OR = 1.59，95%CI：1.17～2.15，P = 0.003）；冠心病组MTHFR C677 CT等位基因表达与正常组比较，差异无统计学意义（OR = 0.91，95%CI：0.76～1.09，P = 0.30）；冠心病组MTHFR C677 TT等位基因表达高于正常组（OR = 0.64，95%CI：0.52～0.79，P ＜ 0.000 01）。结论 MTHFR C677T基因表达与中国人群冠心病发病相关，冠心病人群中TT等位基因表达较高。

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	刘承铭1 庞军2▲ 胡文钰3 汤安英3 吴强2 黄晶2 周瑜2 刘微2

关键词 ：冠心病, MTHFR C677基因, 基因多态性, 中国人群, meta分析

Abstract：Objective To systematically evaluate the association between the incidence of coronary artery heart disease and the MTHFR C677 allele in China. Methods Case-control studies on the correlation between coronary artery heart disease and MTHFR C677 C/T gene were searched in English databases (PubMed, Embase, Cochrane Library) and Chinese databases (CNKI, VIP, Wanfang Data) from inception to February 2021. The quality of the included literatures was evaluated. Data were meta-analyzed using RevMan 5.0 software. Results A total of 2412 cases were included in eight studies, including 1501 cases in the coronary artery heart disease group and 911 cases in the normal group. Meta-analysis showed that the expression of MTHFR C677 CC allele in coronary artery heart disease group was lower than that in normal group (OR = 1.59, 95%CI: 1.17-2.15, P = 0.003). There was no significant difference in MTHFR C677 CT allele expression between coronary artery heart disease group and normal group (OR = 0.91, 95%CI: 0.76-1.09, P = 0.30). The expression of MTHFR C677 TT allele in coronary artery heart disease group was higher than that in normal group (OR = 0.64, 95%CI: 0.52-0.79, P ＜ 0.000 01). Conclusion The expression of MTHFR C677T gene is related to the incidence of coronary artery heart disease in Chinese population, and the TT allele expression is higher in coronary artery heart disease population.

Key words： Coronary artery heart disease MTHFR C677 gene Gene polymorphism Chinese population Meta-analysis

基金资助:贵州省基础研究计划项目[黔科合基础（2019）1190号]；
贵州省科学技术厅临床研究中心项目[黔科合平台人才（2017）5405号]。

通讯作者: ▲通讯作者

引用本文:

刘承铭1 庞军2▲ 胡文钰3 汤安英3 吴强2 黄晶2 周瑜2 刘微2. 中国人群MTHFR C677基因多态性与冠心病发病相关性的meta分析[J]. 中国医药导报, 2021, 18(32): 78-82.
LIU Chengming1 PANG Jun2▲ HU Wenyu3 TANG Anying3 WU Qiang2 HUANG Jing2 ZHOU Yu2 LIU Wei2. Meta-analysis of the relationship between MTHFR C677 gene polymorphism and coronary artery heart disease in Chinese population#br#. 中国医药导报, 2021, 18(32): 78-82.

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https://www.yiyaodaobao.com.cn/CN/ 或 https://www.yiyaodaobao.com.cn/CN/Y2021/V18/I32/78

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