Expression and clinical significance of FAM83D in pancreatic cancer#br#
MIAO Yufeng1 ZHANG Youwei2 JIAO Nanlin3
1.Department of Medical Oncology, the First People’s Hospital of Wenling, Zhejiang Province, Wenling 317500, China;
2.Department of Medical Oncology, Xuzhou Central Hospital, Jiangsu Province, Xuzhou 221009, China;
3.Department of Pathology, Yijishan Hospital, Wannan Medical College, Anhui Province, Wuhu 241001, China
Abstract：Objective To investigate the expression and clinical significance of FAM83D in pancreatic adenocarcinoma (PAAD) tissues. Methods The gene expression and prognosis of FAM83D were analyzed online by Gene Expression Profiling Interactive Analysis (GEPIA) tool, and verified by KMplot database; 60 pairs of paraffin blocks were selected after PAAD operation in the Department of Pathology, Yijishan Hospital, Wannan Medical College from January 2018 to December 2019, including cancer tissues and adjacent tissues, and immunohistochemistry (IHC) was used to detect the expression of FAM83D protein; the mechanism of FAM83D was analyzed by gene set enrichment analysis. Results Compared with normal tissues, the expression of FAM83D mRNA was significantly increased in tumor tissues (P < 0.01). Compared with adjacent tissues, IHC score of cancer tissues was significantly higher (P < 0.01). The high expression of FAM83D protein in PAAD patients was associated with lymph node metastasis (P < 0.05). Compared with the low expression of FAM83D mRNA group, the overall survival and progression-free survival in the high expression of FAM83D mRNA group were significantly shorter (P < 0.01). FAM83D up-regulation was positively correlated with multiple gene sets(P < 0.05). Conclusion FAM83D plays an important role in the occurrence and development of PAAD and is expected to become a potential therapeutic target and a novel molecular marker.
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