Research on application rule of traditional Chinese medicine in erosive oral lichen planus based on data mining#br#
WANG Xueting1 LIN Lin2 GUO Ruitong1 XU Jiagen1 WU Mengmeng1 WANG Xiang2
1.Department of Pharmacy, Stomatological Hospital Affiliated to Medical School of Nanjing University Nanjing Stomatological Hospital, Jiangsu Province, Nanjing 210000, China;
2.Department of Oral Mucosal Disease, Stomatological Hospital Affiliated to Medical School of Nanjing University Nanjing Stomatological Hospital, Jiangsu Province, Nanjing 210000, China
Abstract：Objective To explore the laws of composition and medication of traditional Chinese medicine in the treatment of erosive oral lichen planus (EOLP) based on data mining technology. Methods CNKI, Wanfang and VIP database were retrieved. The relevant literatures on traditional Chinese medicine in the treatment of EOLP were searched with “erosive oral lichen planus” “EOLP” “oral erosion” “Chinese medicine” as retrieval words. The retrieval time limit was from the establishment of each database to June 2020. The nature and taste, meridian and category of traditional Chinese medicine were statistically analyzed, and the association rules and cluster analysis were carried out. Results A total of 83 prescriptions were collected, involving 141 kinds of Chinese medicine. There were 37 kinds of Chinese medicines with medication frequency more than eight times, most of which were Radix Angelicae Sinensis, Radix Rehmanniae Recens, Radix Glycyrrhizae, Cortex Moutan Radicis, Radix Scutellariae. The liver meridian was the main meridian; the main medicinal properties were cold and sweet; most of the drugs were clearing heat and cooling blood drugs, tonifying deficiency and tonifying qi drugs, clearing heat and dispelling dampness drugs. Thirty-eight Chinese medicine combinations with high support were obtained by association analysis, and six cluster groups were obtained by systematic cluster analysis. Conclusion The treatment of EOLP with traditional Chinese medicine mainly focuses on clearing heat and removing toxicity, tonifying deficiency and qi, promoting blood circulation and removing blood stasis, supplemented by soothing liver and invigorating spleen, nourishing yin and reducing fire. Its medication law can provide reference for clinical treatment and new drugs research and development.
王雪婷1 林琳2 郭芮彤1 徐家根1 吴萌萌1 王翔2. 基于数据挖掘探究糜烂型口腔扁平苔藓的中药应用规律[J]. 中国医药导报, 2021, 18(31): 123-127.
WANG Xueting1 LIN Lin2 GUO Ruitong1 XU Jiagen1 WU Mengmeng1 WANG Xiang2. Research on application rule of traditional Chinese medicine in erosive oral lichen planus based on data mining#br#. 中国医药导报, 2021, 18(31): 123-127.
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