Short-term clinical observation of Belimumab in the treatment of systemic lupus erythematosus#br#
XU Lei1 ZHU Yun2 ZHANG Hao1
1.Graduate School of Clinical Medicine, Weifang Medical University, Shandong Province, Weifang 261053, China;
2.Department of Rheumatology and Immunology, Weifang People’s Hospital, Shandong Province, Weifang 261041, China
Abstract：Objective To evaluate the efficacy and safety of Belimumab in the treatment of systemic lupus erythematosus（SLE）. Methods A total of 42 patients who were diagnosed with SLE from the Department of Rheumatology and Immunology, Weifang People’s Hospital from September 2019 to August 2020 were selected. According to the treatment regimen, patients were divided into SoC (stand of care) group (21 cases) and Belimumab group (21 cases) (standard treatment + Belimumab). The clinical efficacy, complement, immunoglobulin G (IgG) levels were compared between the two groups, hormone dose, disease activity index (SLEDAI), and, adverse events were compared between the two groups. Results After treatment, the total effective rate of Belimumab group was higher than that of SoC group, and the difference was statistically significant (P ＜ 0.05). C3 and C4 in the two groups were higher than before treatment, and IgG was lower than before treatment. Complement C3 and C4 in Belimumab group were higher than SoC group, and IgG was lower than SoC group, with statistical significance (P ＜ 0.05); there was no significant difference in hormone dose between the two groups (P ＞ 0.05), SLEDAI score of the two groups was lower than before treatment, and Belimumab group was lower than SoC group, the differences were statistically significant (P ＜ 0.05); there was no significant difference in the total incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Belizumab can improve the therapeutic effect in patients with systemic lupus erythematosus and is safe.
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