细胞焦亡在动脉粥样硬化中的作用及其研究进展

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摘要细胞焦亡是一种新型程序性细胞死亡方式，与凋亡、坏死等传统细胞死亡在形式上有显著差异。动脉粥样硬化性心血管疾病严重影响居民身心健康。近来研究发现血管内皮细胞、巨噬细胞、平滑肌细胞均会发生焦亡，影响动脉粥样硬化病变的发展进程。本文拟综合阐述细胞焦亡与动脉粥样硬化的关系，期望可以给心血管疾病的临床治疗带来新的思考，提供新的可能。

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	徐璐1 王贺2 岳珂1 魏珂1 解金红2 关怀敏2

关键词 ：细胞焦亡, 动脉粥样硬化, 胱天蛋白酶-1, 心血管疾病, 炎症反应

Abstract：Pyroptosis is a new type of programmed cell death, which is significantly different in form from traditional cell death such as apoptosis and necrosis. Atherosclerotic cardiovascular disease seriously affects the physical and mental health of residents. Recent studies have found that vascular endothelial cells, macrophages and smooth muscle cells all experience pyroptosis, which affects the development process of atherosclerosis. This article intends to review the relationship between pyroptosis and atherosclerosis, in order to provide new ideas and find new directions for the treatment of cardiovascular diseases.

Key words： Pyroptosis Atherosclerosis Caspase-1 Cardiovascular diseases Inflammation

基金资助:国家自然科学基金资助项目（81473507）；
河南省中医管理局资助项目（2019ZYZD04）。

通讯作者: 关怀敏（1957.2-），男，博士，主任医师，教授，硕士生导师；研究方向：心血管疾病介入治疗的基础与临床研究。

作者简介: 徐璐（1994.10-），女，河南中医药大学2018级心血管专业在读硕士研究生；研究方向：细胞焦亡致动脉粥样硬化的机制研究。

引用本文:

徐璐1 王贺2 岳珂1 魏珂1 解金红2 关怀敏2. 细胞焦亡在动脉粥样硬化中的作用及其研究进展[J]. 中国医药导报, 2021, 18(31): 46-49.
XU Lu1 WANG He2 YUE Ke1 WEI Ke1 XIE Jinhong2 GUAN Huaimin2. Research progress on pyroptosis and its role in atherosclerosis#br#. 中国医药导报, 2021, 18(31): 46-49.

链接本文:

https://www.yiyaodaobao.com.cn/CN/ 或 https://www.yiyaodaobao.com.cn/CN/Y2021/V18/I31/46

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