Clinical effect of Self-made Huatan Tongluo Prescription in the treatment of acute cerebral infarction with syndrome of wind-phlegm obstructing collateral#br#
TONG Xiaoling1 CHENG Xiaojing2 ZHANG Lianwen3
1.Department of Encephalopathy, Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Beijing 100039, China;
2.Tumor Transformation Laboratory, Beijing Cancer Hospital, Beijing 100142, China;
3.Jingxi Medical District, Chinese PLA General Hospital, Beijing 100091, China
Abstract：Objective To observe the clinical effect of Self-made Huatan Tongluo Prescription in the treatment of acute cerebral infarction patients with syndrome of wind-phlegm obstructing collateral. Methods From January 2019 to August 2020, a total of 60 patients with acute cerebral infarction admitted to Department of Encephalopathy in Beijing Hospital of Integrated Traditional Chinese and Western Medicine were selected as the research subject. They were divided into control group and treatment group according to the random number table method, with 30 cases in each group. Both groups were given conventional treatment, on the basis of the control group, the treatment group was added with Huatan Tongluo Prescription, the total course of both groups was four weeks. Traditional Chinese medicine (TCM) syndrome scores, National Institutes of Health stroke scale (NHISS) scores, Barthel index (BI) scores before and after treatment were observed in both groups, and the difference of clinical efficacy in both groups was compared. Results After treatment, TCM syndrome scores and NHISS scores in both groups were lower than those before treatment, BI scores were higher than those before treatment, and TCM syndrome score and NHISS score in the treatment group were significantly lower than those in the control group, BI score was significantly higher than that of the control group, the differences were statistically significant (P ＜ 0.05). The clinical efficacy of the treatment group was significantly better than that of the control group (P ＜ 0.05). Conclusion The self-made Huatan Tongluo Prescription has a remarkable effect in the treatment of acute cerebral infarction with syndrome of wind-phlegm obstructing collateral, which can obviously improve the neurological deficit symptoms of acute cerebral infarction patients, relieve TCM syndrome, and increase the patients’ quality of life.
[1] 陈灏珠.实用内科学[M].北京：人民卫生出版社，2001：2428．
[2] 张莎，冯玥，仇丽霞.急性脑梗死中医证型与相关因素关系研究[J].中国医药导报，2019，16（35）：103-106.
[3] Deguchi I，Tanahashi N，Takao M. Clinical Study of Intravenous，Low-Dose Recombinant Tissue Plasminogen Activator for Acute Cerebral Infarction：Comparison of Treatment within 3 Hours versus 3-4.5 Hours [J]. J Stroke Cerebrovasc Dis，2018，27（4）：1033-1040.
[4] Anderson CS，Robinson T，Lindley RI，et al. Low-dose versus standard-dose intravenous alteplase in acute ischemic stroke [J]. N Engl J Med，2016，374（24）：2313-2323.
[5] Matsuo R，Kamouchi M，Ago T，et al. Thrombolytic therapy with intravenous recombinant tissue plasminogen activator in Japanese older patients with acute ischemic stroke：the Fukuoka Stroke Registry [J]. Geriatr Gerontol Int，2014，14（4）：954-959.
[6] 李家邦.中医学[M].7版.北京：人民卫生出版社，2008：151-322.
[7] 蔡秀英，王振，师淑花.化痰通络汤治疗急性脑梗死（痰瘀阻络证）疗效及对血小板参数的影响[J].中国中医急症，2021，30（5）：846-848.
[8] 林成才，李丽娟，陈吉波，等.缺血性中风中经络辨证分型与颅脑MRA表现的关系[J].中国中医急症，2019，28（8）：1444-1446.
[9] 中华医学会神经病学分会，中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2018[J].中华神经科杂志，2018，51（9）：666-682.
[10] 国家中医药管理局脑病急症协作组.中风病诊断与疗效评定标准（试行）[J].北京中医药大学学报，1996，19（1）：55-56.
[11] Kitaji Y，Harashima H，Miyano S. Relationship between first mobilization following the onset of stroke and clinical outcomes in patients with ischemic stroke in the general ward of a hospital：A cohort study [J]. Phys Ther Res，2020，23（2）：209-215.
[12] 闵瑜，吴媛媛，燕铁斌.改良Barthel指数（简体中文版）量表评定脑卒中患者日常生活活动能力的效度和信度研究[J].中华物理医学与康复杂志，2008，3（3）：185-188.
[13] 郑筱萸.中药新药临床研究指导原则（试行）[S].北京：中国医药科技出版社，2002：253-258.
[14] Wang W，Jang B，Sun H，et al. Prevalence，Incidence，and Mortality of Stroke in China：Resuhs from a Nationwide Population-Based Survey of 480 687 Adults [J]. Circulation，2017，135（8）：759-771.
[15] 徐振兴，陈进春，邱明山，等.化痰通络方对IL-1β刺激的RA滑膜成纤维细胞增殖及TNF-α和aFGF的影响[J].中国中西医结合杂志，2017，37（1）：101-105.
[16] 彭成.中药药理学[M].3版.北京：中国中医药出版社，2015：272.
[17] 彭成.中药毒理学[M].北京：中国中医药出版社，2014：86-88.
[18] Heena A，Ubaid Y. Traditional uses，phytochemistry，pharmacology and toxicity of Arisaema（Areaceae）：a review [J]. Bull Natl Res Cent，2021，45：47-65.
[19] Peng Z，Wang S，Chen G，et al. Gastrodin alleviates cerebral ischemic damage in mice by improving anti-oxidant and anti-inflammation activities and inhibiting apoptosis pathway [J]. Neurochem Res，2015，40（4）：661-673.
[20] Lao CJ，Lin JG，Kuo JS，et al. Effects of Salvia Miltiorrhiza Bunge on cerebral infarct in ischemia-reperfusion injured rats [J]. Am J Chin Med，2003，31（2）：191-200.
[21] Zhou L，Zuo Z，Chow MSS. Danshen：an overview of its chemistry，pharmacology，pharmacokinetics and clinical use [J]. J Clin Pharmacol，2005，45（12）：1345-1359.
[22] Chen Y，Wu X，Yu S，et al. Neuroprotective capabilities of Tanshinone ⅡA against cerebral ischemia/reperfusion injury via anti-apoptotic pathway in rats [J]. Biol Pharm Bull，2012，35（2）：164-170.
[23] Zeng X，Zhang Y，Zhang S，et al. A microdialysis study of effects of gastrodin on Neurochemical changes in the ischemic/reperfused rat cerebral hippocampus [J]. Biol Pharm Bull，2007，30（4）：801-804.
[24] Pang YQ，Zhu SZ，Pei HT. Pachymic acid protects against cerebral ischemia/reperfusion injury by the PI3K/Akt signaling pathway [J]. Metab Brain Dis，2020，35（4）：673-680.
[25] Chen YT，Sun CK，Lin YC，et al. Adipose-derived mesenchymal stem cell protects kidneys against ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reaction [J]. J Transl Med，2011，9（1）：51.
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